In vitro Blood-Brain Barrier Assay

The blood-brain barrier (BBB) is formed by endothelial cells of cerebral capillaries and microvessels, coming in close contact with neighboring pericytes and glial cells. As an active interface between the circulation and the central nervous system (CNS), the BBB strictly controls the molecular and cellular traffic between the blood and the brain, thus taking an essential share in providing a steady-state environment for the proper neuronal function.

The BBB protects brain nervous tissue from fluctuating plasma composition from pathogenic agents and maintains homeostasis of the brain parenchyma by restricting non-specific flux of ions, peptides, proteins, and even cells into and out the brain. Many drugs developed to treat CNS disorders are unable to reach the brain parenchyma in therapeutically relevant concentrations. Therefore, it is crucial to characterize the BBB permeability of a drug candidate as early as possible in the developmental drug pipeline. In order to meet this need, in vitro models of the BBB have been developed.

With decades of operational experience and technology platform of BBB research, Creative Bioarray has established multiple in vitro Blood-Brain Barrier Models.