I’m glad to join the Cloud Scientist Community!

Hello everyone! I have successfully joined Cloud Scientist program！

I’m Xiyun Deng, a professor of Pathophysiology and Molecular Pathology and chair of Department of Basic Medical Sciences. I’m the founder and serves as director of Key Laboratory of Translational Cancer Stem Cell Research at Hunan Normal University. My research, which has been funded by the NSFC and other funding agencies for over 15 years, focuses on the experimental therapeutics targeting cancer stem cells. My team discovered that post-translational modifications of non-histone proteins play a crucial role in metastasis and drug-induced cellular stress responses in cancer stem cells, upon which we proposed the concept of “reverse nucleolar stress”. My work led to the development and mechanistic elucidation of cancer stem cell-targeting drugs (including a patented nanocarrier-based composite drug) particularly against triple-negative breast cancer. 

RESEARCH FUNDING (as Principal Investigator)  

1)    2012.12-2022.11            Amount: ¥1,600,000

           Role and mechanisms of cell metabolism in cancer metastasis (Grant # 130608)

           Supported by Hunan Normal University (HUNNU)

2)    2019.01-2022.12            Amount: ¥580,000 (direct cost)

Studies on the mechanisms by which lovastatin inhibits TNBC cancer stem cells via nucleolar stress-mediated autophagy (Grant # 81872167)  

           Supported by Natural Science Foundation of China (NSFC)

3)    2015.01-2018.12            Amount: ¥700,000

Inhibition of EMT and metastasis by lovastatin through targeting breast cancer stem cells and the mechanisms involved (Grant # 81472496)

           Supported by Natural Science Foundation of China (NSFC)

4)    2008.01-2010.12            Amount: ¥320,000

Molecular mechanisms by which Epstein-Barr virus-encoded latent membrane protein 1 regulates the activity of chemokine receptor CXCR4 and promotes nasopharyngeal carcinoma metastasis (Grant # 30771966)

           Supported by Natural Science Foundation of China (NSFC)

5)    2002.01-2003.12            Amount: ¥160,000

Role of the chemokine receptor EBI1/CCR7 in the metastasis of nasopharyngeal carcinoma (Grant # 30170877)

           Supported by Natural Science Foundation of China (NSFC)

6)    2019.01-2021.12            Amount: ¥100,000

Studies on the mechanisms of the inhibitory effects of lovastatin on TNBC cancer stem cells via upregulation of p14^ARF and induction of nucleolar stress (Grant # 2019JJ40193)

Supported by Department of Science and Technology of Hunan

7)    2014.09-2017.08            Amount: ¥60,000

Experimental studies of inhibition of metastasis by Monacolin K through targeting breast cancer stem cells (Grant # 14A089) 2019JJ40193

Supported by Department of Education of Hunan

8)    2014.10-2016.09            Amount: ¥50,000

Inhibition of breast cancer stem cells by Monacolin K through chemosensitization (Grant # k1403024-31)

Supported by Bureau of Science and Technology of Changsha

9)    2001.01-2002.12           Amount: ¥5,000

Identification of nasopharyngeal carcinoma metastasis-related chemokines and their receptors

Supported by Hunan Province Health Bureau 

Welcome to leave a comment if you are interested in our research！