Zhiheng Xu

Dr. Zhiheng Xu received his doctoral degree in Waksman Institute, Rutgers University in 1999. His doctoral research was under the guidance of Dr. David Norris and focused on cell cycle and DNA damage checkpoints, meiosis, and histone acetyl-transferase. He then did 4 years postdoctoral research on apoptosis and neurodegenerative diseases in Columbia University, under the guidance of Dr. Lloyd A. Greene and became an Associate Scientist in 2003. From 2004 to now, he is a Principle investigator at Institute of Genetics and Developmental Biology, Chinese Academy of Sciences. Dr. Xu’s group uses molecular, biochemical and cellular biological methods to study the roles and regulatory mechanisms of different protein kinase complexes in signal transduction pathways, revealed the significance of JNK signaling pathway in the pathological process of neurogenesis, tumor and neurodegenerative diseases. They also stablish and study the pathogenesis of microcephaly, schizophrenia, autism and neurodegenerative diseases in genetically manipulated mouse models. His accomplishments in Zika virus study has been highlighted by Nature, Science, PNAS et al. and covered by 100 media.

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Institute of Genetics and Developmental Biology, Chinese Academy of Sciences

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  1. Xu D, Li C, Qin CF, Xu Z*(2019) Update on the Animal Models and Underlying Mechanisms for ZIKV-Induced Microcephaly. Annu. Rev. Virol. doi.org/10.1146/annurev-virology-092818-015740.

  2. Nielsen-Saines K, Xu Z, Cheng G, Moreira (2019) Early childhood neurodevelopmental outcomes in a prospective cohort of in utero ZIKV-1 exposed children from Rio de Janeir, Nat Med (in press).

  3. Li H, Saucedo-Cuevas L, Yuan L, Ross D, Johansen A, Sands D, Stanley V, Guemez-Gamboa A, Gregor A, Evans T, Chen S, Tan L, Molina H, Sheets N, Shiryaev SA, Terskikh AV, Gladfelter AS, Shresta S, Xu Z, Gleeson JG. (2019).Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors. Neuron. 20;101(6):1089-1098.e4. doi: 10.1016/j.neuron.2019.01.010.

  4. Chang YF, Jiang YS, et al., Xu Z* (2019) Dissecting of the Gene Networks Affected by Zika Virus Infection in a Mouse Microcephaly Model. Genomics Proteomics & Bioinformatics (accepted).

  5. Wang XT et al., Xu Z*, Shen Y* (2019) MEA6 deficiency impairs cerebellar development and motor performance by tethering protein trafficking. Frontiers in Cellular Neuroscience (in press)

  6. Xu YP, Qiu Y, Zhang B, Chen G, Chen Q, Wang M, Mo F, Xu J, Wu J, Zhang RR, Cheng ML, Zhang NN, Lyu B, Zhu WL, Wu MH, Ye Q, Zhang D, Man JH, Li XF, Cui J, Xu Z, Hu B, Zhou X, Qin CF. (2019) Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids. Cell Res. 2019 Apr;29(4):265-273. doi: 10.1038/s41422-019-0152-9.

  7. Xu D., Zhu Y., and Xu Z*. (2018) MEKK3 Coordinates with FBW7 to Regulate WDR62 Stability and Neurogenesis. PLoS Biology 19;16(12):e2006613. doi: 10.1371/journal.pbio.2006613

  8. Wang S. et al., Xu Z*. (2018). Sh3rf2 haploinsufficiency leads to unilateral neuronal development deficits and autistic-like behaviors in mice. Cell Reports DOI:10.1016/j.celrep.2018.11.044


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