Yulong Li

Dr. Yulong Li received PhD degree for his study in the area of Neurobiology at Duke University, and he was Postdoctoral Fellow at Stanford University from 2006 to 2012. At present, as Principle Investigator at Peking University, Dr. Li continues his research interest in neurons. Li research lab carries out research in a layered manner that encompasses both the aspect of development of novel investigation tools and of the study centered on the regulation of synaptic transmission, facilitated by those advancing research toolkits. For the tools’ side, they work on the development of non-invasive systems for opto-genetic mapping of electric synapses, together with that of genetically-encoded sensors for imaging neurotransmitters/modulators. With the tools, Li lab’s study focuses on the modulation of presynaptic transmitter release in health (e.g. sleep) and in disease conditions (e.g. neurodegenerative disease). Recently, the functional studies concentrate on the discovery and analysis of novel small molecule NT, the proteomic mapping of LDCV, and the correlating the novel transmitters with receptors. Dr. Li and his group is also studying how high brain centers are controlled during perception (olfaction) or sleep using fly and mice as model systems.

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Peking University

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GRAB Sensors 0 Synaptic Transmission 0 Large Dense Core Vesicles (LDCV) 0 Opto-genetics, Neurotransmitters 0 Neurotransmitter Receptors 0

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  1. Hamilos, A. E., Spedicato, G. Hong, Y., Sun, F., Li, Y. & Assad, J. A.* (2020). Dynamic dopaminergic activity controls the timing of self-timed movement.

  2. Wu, Z., Cui, Y., Wang, H., Song, K., Yuan, Z., Dong, A., Wu, H., Wan, Y., Pan, S., Peng, W., Jing, M., Xu, M., Luo, M. & Li, Y. *(2020). A GRAB sensor reveals activity-dependent non-vesicular somatodendritic adenosine release.

  3. Crouse,R. B., Kim, K., Batchelor, H. M., Kamaletdinova, R., Chan, J., Rajebhosale, P., Pittenger, S. T., Role, L. W., Talmage, D A., Jing, M. , Li, Y., Gao, X., Mineur , Y. S., & Picciotto, M. R. * (2020). Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances learning of cue-reward contingency.

  4. Feng, J., Zhang, C., Lischinsky, J. E., Jing, M., Zhou, J., Wang, H., Zhang, Y., Dong, A., Wu, Z., Wu, H., Chen, W., Zhang, P., Zou, J., Hires, S. A., Zhu, J. J., Cui, G., Lin, D., Du, J. & Li, Y.* (2019). A genetically encoded fluorescent sensor for rapid and specific in vivo detection of norepinephrine. Neuron, 102(4), 745-761.

  5. Sun, F.#, Zeng, J.#, Jing, M.#, Zhou, J., Feng, J., Owen, S., Luo, Y., Li, F., Wang, H., Yamaguchi, T., Yong, Z., Gao, Y., Peng, W., Wang, L., Zhang, S., Du, J., Lin, D., Xu, M., Kreitzer, A. C., Cui, G. & Li, Y.* (2018). A genetically-encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice. Cell, 174(2), 481-496.

  6. Jing, M.#, Zhang, P.#, Wang, G., Feng, J., Mesik, L., Zeng, J., Jiang, H., Wang, S., Looby, J. C., Guagliardo, N. A., Langma, L. W., Lu, J., Zuo, Y., Talmage, D. A., Role, L. W., Barrett, P. Q., Zhang, L. I., Luo, M., Song, Y., Zhu, JJ* & Li, Y*. (2018). A genetically-encoded fluorescent acetylcholine indicator for in vitro and in vivo studies. Nature Biotechnology, 36(8), 726-737.


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