Tracy Bryan

Professor Tracy Bryan is head of the Cell Biology Unit at Children’s Medical Research Institute (CMRI), where she leads the research programmes concentrate on the enzyme telomerase. Telomerase is a vital element of chromosome and plays an important role in cell fates, as it determines the termination of cell cycles by shortening during every cycle of DNA replication and cell division; telomerase is expressed in ≥85% of all human cancers its maintenance mechanisms in cancer cells are hence regarded as potential targets for anticancer therapeutics. During her Ph.D. at the CMRI, she discovered a new mechanism for maintenance of the telomers in human tumours, called ALT, while currently, her research aims to develop small-molecule inhibitors of telomerase as potential anti-cancer therapeutics, upon the basis of comprehensive understanding of telomerase biology, which includes association with its telomeric DNA substrate, active recruitment of telomerase to the telomere, telomerase enzymology, and structure.

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The Cell Biology Unit/ Tracy Bryan’ Laboratory, Children’s Medical Research Institute

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G-quadruplexes 0 Anticancer Therapeutics 0 Telomerase 0 Telomerase Reverse Transcriptase 0 DNA Replication and Repair 0

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  1. Paudel BP, Moye AL, Abou Assi H, et al. A mechanism for the extension and unfolding of parallel G-quadruplexes by human telomerase at single-molecule resolution [published online ahead of print, 2020 Jul 29]. Elife. 2020;9:e56428. doi:10.7554/eLife.56428

  2. Perera ON, Sobinoff AP, Teber ET, et al. Telomerase promotes formation of a telomere protective complex in cancer cells. Sci Adv. 2019;5(10):eaav4409. Published 2019 Oct 2. doi:10.1126/sciadv.aav4409

  3. Le TYL, Pickett HA, Yang A, et al. Enhanced cardiac repair by telomerase reverse transcriptase over-expression in human cardiac mesenchymal stromal cells. Sci Rep. 2019;9(1):10579. Published 2019 Jul 22. doi:10.1038/s41598-019-47022-w

  4. Tomlinson GG, Moye AL, Holien JK, Parker MW, Cohen SB, Bryan TM. Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding. Biochem. 2014, Nov 3. doi: 10.1042/BJ20140922. PMID: 25365545

  5. Bryan TM, Englezou A, Gupta J, Bacchetti S and Reddel RR. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 1995, 14: 4240-4248. PMID: 7556065.


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