Tak W. Mak

Prof. Tak Wah Mak is famous for his discovery of T Cell Receptors in 1983, while in 1995, he made another breakthrough in the area of immunology via the discovery of CTLA-4 immune checkpoint protein. Currently as a senior scientist at Princess Margaret Cancer Center, he is leading research that concentrates on the mechanisms underlying immune responses and tumourigenesis. Prof. Mak and his team are carrying out complementary projects, covering the immune system, programed cell death and pathogenesis of cancer based on mouse models which are specifically engineered for distinct experiand mental designs. Mak’s team is also transforming the key molecules in the pathogenic pathways into functional therapeutic targets.

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University Health Network

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Immunology 0 Immunotherapies 0 Apoptosis 0 Oncology 0 T Cell Activation 0

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  2. Beck S, Zickler M, Pinho Dos Reis V, et al. ANP32B Deficiency Protects Mice From Lethal Influenza A Virus Challenge by Dampening the Host Immune Response. Front Immunol. 2020;11:450. Published 2020 Mar 13.

  3. Kurniawan H, Franchina DG, Guerra L, et al. Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function. Cell Metab. 2020;31(5):920-936.e7.

  4. Omori H, Nishio M, Masuda M, et al. YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma. Sci Adv. 2020;6(12):eaay3324. Published 2020 Mar 18.

  5. Fortin J, Tian R, Zarrabi I, et al. Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas. Cancer Cell. 2020;37(3):308-323.e12.


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