Tae-Hee Kim

Dr. Tae-Hee Kim is awarded his PhD degree of Cell Biology and Genetics from the Howard Hughes Medical Institute, Cornell University and Sloan Kettering Institute, USA, in 2006, and following which he worked as a post-doctoral fellow at Dana-Farber Cancer Institute. At present, Dr. Kim is scientist at The Hospital for Sick Children and meanwhile Assistant Professor of University of Toronto, Canada. The ongoing research in the Kim Lab emphasized on two questions: 1. How different organs and cell types are generated from stem cells and maintained for proper function over a lifetime. 2. How mechanisms of normal stem cell homeostasis may be altered in diseases such as cancer. The lab uses the gut as a model system, as it encompasses a high cell turnover rate because of the stem cells activities, and is a common target of diseases especially cancer; combined approaches including mouse genetics, stem cell organoid culture, and epigenetics analysis are employed. Dr. Kim and his group hopes that understanding stem cell homeostasis in gut development and disease will provide insights into the relationship between normal development and mechanisms of disease, and help identify new therapeutic targets for lethal digestive tract cancers and regenerative medicine.

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The Hospital for Sick Children

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Stem Cell Homeostasis 0 Gastrointestinal Tract 0 Genetics 0

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  1. Kim, J., Fei, L., Yin, W. et al. Single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches. Nat Commun 11, 334 (2020).

  2. Rao-Bhatia A, Zhu M, Yin WC, Coquenlorge-Gallon S, Zhang X, Woo JH, Dean CH, Liu A, Hui CC, Shivdasani RA, McNeill H, Hopyan S, Kim T-H. Fat4-Dchs1 and planar cell polarity pathways activated by Hedgehog mediate mesenchymal clustering and villus formation during mammalian gut development. Developmental Cell (2020) March 9, 52(5):647-658.

  3. Francis R, Guo H, Ahmed M, Yung T, Dirks PB, He HH, Kim T-H. Gastrointestinal transcription factors drive lineage-specific developmental programs in organ specification and cancer. Science Advances (2019) Dec 11;Vol 5 no. 12, eaax8898.

  4. Yung, T., Poon, F., Liang, M. et al. Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals. Nat Commun 10, 4647 (2019).

  5. Zhang Y, Kim TH, Niswander L. Phactr4 regulates directional migration of enteric neural crest through PP1, integrin signaling, and cofilin activity. Genes Dev. 2012;26(1):69-81.


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