Susanne Wegmann

Dr. Susanne Wegmann obtained a PhD in Biophysics at the Eidgenössische Technische Hochschule, Zürich, and completed postdoctoral study with Prof. Dr. Bradley T. Hyman at Massachusetts General Hospital & Harvard Medical School in Boston. She is currently leading a research group at the DZNE in Berlin, with a central research topic on the “Protein Actions in Neurodegenerative Diseases “. Her group utilized a wide spectrum of experimental methodologies and techniques – from biophysical and biochemical techniques, to cell culture and animal models, and to postmortem human tissue - to discover the actions that proteins take during their normal function and during misfunction in the diseased brain. Recently, the Wegmann lab is interested in the intrinsically unfolded neuronal microtubule-associated tau protein, which aggregates in multiple different neurodegenerative diseases. They are investigating the many unknown functions of tau proteins, which can provide insights on their toxicity effects and reveal novel therapeutic targets; one research direction of the group is the tau’s interaction with intracellular molecules and structures, and they showed that tau can inhibit the functions of nucleoporins.

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German Center for Neurodegenerative Disease

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Tau Proteins 0 Neurodegenerative Diseases 0 Alzheimer’s Disease 0 Microscopy 0

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  1. Rauch JN, Luna G, Guzman E, et al. LRP1 is a master regulator of tau uptake and spread. Nature. 2020;580(7803):381-385. doi:10.1038/s41586-020-2156-5

  2. Eftekharzadeh B, Daigle JG, Kapinos LE, et al. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease [published correction appears in Neuron. 2019 Jan 16;101(2):349]. Neuron. 2018;99(5):925-940.e7. doi:10.1016/j.neuron.2018.07.039

  3. Wegmann S, Eftekharzadeh B, Tepper K, et al. Tau protein liquid-liquid phase separation can initiate tau aggregation. EMBO J. 2018;37(7):e98049. doi:10.15252/embj.201798049

  4. Busche MA, Wegmann S, Dujardin S, et al. Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo. Nat Neurosci. 2019;22(1):57-64. doi:10.1038/s41593-018-0289-8

  5. Kara E, Marks JD, Roe AD, et al. A flow cytometry-based in vitro assay reveals that formation of apolipoprotein E (ApoE)-amyloid beta complexes depends on ApoE isoform and cell type. J Biol Chem. 2018;293(34):13247-13256. doi:10.1074/jbc.RA117.001388


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