Qiang Wu
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Brain Diseases 0 Proto-cadherin 0 UGT clusters 0 CRISPR DNA-fragment editing 0
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Neutralizing antibodies (NAbs) are critical human immune defense mechanisms against viral infections. NAbs can bind to sites on the virus and inhibit entry of that virus into the host. It is a key parameter to evaluate COVID-19 vaccine efficacy per Guidelines from Development and ...Learn More
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This 3D animation shows you how DNA is copied in a cell. It shows how both strands of the DNA helix are unzipped and copied to produce two identical DNA molecules. TranscriptDNA is a molecule made up of two strands twisted around each other in a double helix shape. Each strand is ...Learn More
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Jia Z., Li J., Ge X., Wu Y., Guo Y., Wu Q. (2020). Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection. Genome Biology 21 (75), 1-24
Wu Q. and Jia Z. (2020). Wiring the Brain by Clustered Protocadherin Neural Codes. Neuroscience Bulletin. https://link.springer.com/article/10.1007/s12264-020-00578-4.
Jia Z. and Wu Q. (2020). Clustered Protocadherins Emerge as Novel Susceptibility Loci for Mental Disorders. Frontiers in Neuroscience 14, 1191.
Wu Q., Liu P. and Wang L. (2020). Many facades of CTCF unified by its coding for three dimensional genome architecture. Journal of Genetics and Genomics 47, 407-424.
Wu Q. and Shou J. (2020). Toward precision CRISPR DNA fragment editing and predictable 3D genome engineering. Journal of Molecular Cell Biology, mjaa060, https://doi.org/10.1093/jmcb/mjaa060.
Wu Y., Jia Z., Ge X., Wu Q. (2020). Three-dimensional genome architectural CCCTC-binding factor makes choice in duplicated enhancers at Pcdhα locus. SCIENCE CHINA Life Sciences, 63: 835-844.
Lu Y., Shou J., Jia Z., Wu Y., Li J., Guo Y., Wu Q. (2019). Genetic evidence for asymmetric blocking of higher-order chromatin structure by CTCF/cohesin. Protein & Cell 10 (12), 914-920
Shi X., J Shou, MM Mehryar, J Li, L Wang, M Zhang, H Huang, X Sun, Q Wu. (2019). Cas9 has no exonuclease activity resulting in staggered cleavage with overhangs and predictable di-and tri-nucleotide CRISPR insertions without template donor. Cell discovery 5 (1), 1-4
Shou J., Li J., Liu Y., Wu Q. (2018) Precise and predictable CRISPR chromosomal rearrangements reveal principles of Cas9-mediated nucleotide insertion. Molecular Cell. 71, 498-509. Epub 2018 Jul 19. Research Highlighted in National Science Review doi.org/10.1093/nsr/nwy156.
Fan L., Lu Y., Shen X., Shao H., Suo L., Wu Q. (2018) Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice. eLife. 7. pii: e35242. doi: 10.7554/eLife.35242. Highlighted in eLife Digest.
Yin, M., Wang, J., Wang, M., Li, X., Zhang, M., Wu, Q., Wang, Y. (2017) Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites. Cell Research 27: 1365-1377.
Chen W.V., Nwakeze C.L., Denny C.A., O'Keeffe S., Rieger M.A., Mountoufaris G., Kirner A., Dougherty J.D., Hen R., Wu Q., Maniatis T. (2017) Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice. Science. 356: 406-411. doi: 10.1126/science.aal3231. Research Highlighted in Perspective in Science, 356: 376-378.
Huang, H. and Wu, Q. (2016). CRISPR Double Cutting through the Labyrinthine Architecture of 3D Genomes. J Genet Genomics. 43: 273-288. Invited Review.
Guo, Y., Q. Xu, D. Canzio, J. Shou, J. Li, D.U. Gorkin, I. Jung, H. Wu, Y. Zhai, Y. Tang, Y. Lu, Y. Wu, Z. Jia, W. Li, M.Q. Zhang, B. Ren, A.R. Krainer, T. Maniatis, Wu Q. (2015). CRISPR inversion of CTCF sites alters genome topology and enhancer/promoter function. Cell 162: 900-910. doi:10.1016/j.cell.2015.07.038. CELL Hottest Article. Research Highlighted in Cell, 162, 703–705; Nature Reviews Molecular Cell Biology 16, 578–579.
Li J, Shou J，Guo Y, Tang Y, Wu Y, Jia Z, Zhai Y, Chen Z, Xu Q, Wu, Q. (2015). Efficient inversions and duplications of mammalian regulatory DNA elements and gene clusters by CRISPR/Cas9. J. Mol. Cell Biol. 7: 284-298. Cover Article.
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