Laura Poliseno

Dr. Laura Poliseno received her doctorate in Molecular Biotechnology from the University of Pisa, Italy. She has worked as a postdoctoral researcher at Memorial Sloan-Kettering and at Beth Israel Deaconess Medical Center, later starting a second post doc fellowship at NYU Langone. Laura is currently a Principal Investigator within the Oncogenomics unit at ISPRO and a researcher at the Institute of Clinical Physiology of the National Research Council in Pisa. Dr. Poliseno’s research has mostly been centered on non-coding RNAs (miRNA, pseudogenes, ceRNAS) and their respective roles in cancer. Recently, her lab has studied the coding and non-coding genetic network that regulates the BRAF and ERK kinase pathways in melanoma. Specifically, the inhibitory effects of the miR-204/miR-211 miRNAs on the BRAF pathway as a potential onco-suppresive agent. She has also studied the use of an attenuated L. monocytogenes, Lm(at)-LLO, as an antitumor agent potentially combining the effects of targeted and immunotherapeutic techniques. Dr. Poliseno aims to translate her findings in in vitro/in vivo melanoma models for related therapies.

Lab Information

Institute of Clinical Physiology of the National Research Council

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Genomics 1 Functional Genetics 0 Non-coding RNA 0 Proteins and Human Diseases 0 Yeast Genetics and Genomics 1 Melanoma 0 Cardiovascular Diseases 1 Cancer Research 0

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Lubrano, S., Comelli, L., Piccirilli, C., Marranci, A., Dapporto, F., Tantillo, E., Gemignani, F., Gutkind, J.S., Salvetti, A., Chiorino, G., Cozza, G., Chiariello, M., Galli, A., Poliseno, L., Cervelli, T. (2019). Development of a yeast-based system to identify new hBRAFV600E functional interactors. Oncogene, 38:1355-1366.

Vitiello, M., Evangelista, M., Di Lascio, N., Kusmic, C., Massa, A., Orso, F., Sarti, S., Marranci, A., Rodzik, K., Germelli, L., Chandra, D., Salvetti, A., Pucci, A., Taverna, D., Faita, F., Gravekamp, C., Poliseno, L. (2019). Antitumoral effects of attenuated Listeria monocytogenes in a genetically engineered mouse model of melanoma. Oncogene.

Marranci, A., Jiang, Z., Vitiello, M., Guzzolino, E., Comelli, L., Sarti, S., Lubrano, S., Franchin, C., Echevarría-Vargas, I., Tuccoli, A., Mercatanti, A., Evangelista, M., Sportoletti, P., Cozza, G., Luzi, E., Capobianco, E., Villanueva, J., Arrigoni, G., Signore, G., Rocchiccioli, S., Pitto, L., Tsinoremas, N., Poliseno, L. (2017). The landscape of BRAF transcript and protein variants in human cancer. Molecular Cancer, 16(1):85.

Vitiello, M., Tuccoli, A., D’Aurizio, R., Sarti, S., Giannecchini, L., Poliseno, L., et al. (2017). Context-dependent miR-204 and miR-211 affect the biological properties of amelanotic and melanotic melanoma cells. Oncotarget, 8(15): 25395-25417.

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