Klaus Aktories

Professor Klaus Aktories’ research interest is focused on cell signaling and its manipulation by bacterial protein toxins. His laboratory studies the interaction of toxins with target cells and the host receptors involved in toxin up-take and intracellular traffic. His group discovered the molecular mechanism of numerous bacterial toxins acting by ADP-ribosylation, glycosylation and deamidation of eukaryotic target proteins. Scientific aims are elucidation of the mode of actions of bacterial protein toxins as a prerequisite for development of anti-infection strategies and to use highly specific and potent toxins as pharmacological tools in cell biology and therapy.

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Albert-Ludwigs-Universität Freiburg

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Cell Signaling 0 Clostridial Glucosylating Toxins 0 Host-pathogen Interaction 0 Anti-Infection Therapeutics 0

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  1. Aktories K, Gierschik P, Heringdorf DMZ, Schmidt M, Schultz G, Wieland T. cAMP guided his way: a life for G protein-mediated signal transduction and molecular pharmacology-tribute to Karl H. Jakobs. Naunyn Schmiedebergs Arch Pharmacol. 2019;392(8):887-911. doi:10.1007/s00210-019-01650-1

  2. Ost GS, Wirth C, Bogdanović X, et al. Inverse control of Rab proteins by Yersinia ADP-ribosyltransferase and glycosyltransferase related to clostridial glucosylating toxins. Sci Adv. 2020;6(11):eaaz2094. Published 2020 Mar 11. doi:10.1126/sciadv.aaz2094

  3. Schwan C, Kruppke AS, Nolke T, Schumacher L, Koch-Nolte F, Kudryashev M, Stahlberg H, and Aktories K Clostridium difficile toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence. Proc Natl Acad Sci U S A 111, 2313-2318 (2014)

  4. Gatsogiannis C, Lang AE, Meusch D, Pfaumann V, Hofnagel O, Benz R, Aktories K, and Raunser S A syringe-like injection mechanism in Photorhabdus luminescens toxins. Nature 495, 520-523 (2013)

  5. Jank T, Bogdanovic X, Wirth C, Haaf E, Spoerner M, Bohmer KE, Steinemann M, Orth JH, Kalbitzer HR, Warscheid B, Hunte C, Aktories K. A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins. Nat Struct Mol Biol 20, 1273-1280 (2013)

  6. Papatheodorou P, Carette JE, Bell GW, Schwan C, Guttenberg G, Brummelkamp TR, and Aktories K. Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT). Proc Natl Acad Sci USA 108, 16422-16427 (2011).

  7. Lang AE, Schmidt G, Schlosser A, Hey TD, Larrinua IM, Sheets JJ, Mannherz H-G, and Aktories K. Photorhabdus luminescens toxins ADP-ribosylate actin and RhoA to force actin clustering. Science 327, 1139-1142 (2010).


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