Karen S Browning

Dr. Karen S Browning received her doctoral degree in 1980 from the University of Illinois. From 1980 to 1982, she worked as a post-doc fellow at MIT. Now, she is a professor of Molecular Biosciences at The University of Texas at Austin. Her research group is seeking a molecular description of the process in which initiation factors (eIF4A, eIF4B, eIF4F, eIF3, eIF2 and PABP) select, prepare and bind messenger RNA to the 40S ribosome. Plants have a unique second form of eIF4F (eIFiso4F), and they are using a variety of methods (genetic knockouts, gene silencing, DNA arrays, etc.) to discover the function of this novel initiation factor. Dr. Karen S Browning’s group are also interested in the features of messenger RNAs that make some messenger RNAs translate more efficiently than others and why plants need two forms of eIF4F. They are using a variety of techniques to study the interactions of initiation factors with each other and with messenger RNAs (expression of cloned factors, site-directed mutagenesis, crystallography, yeast three-hybrid system, fluorescence, etc.). From their studies they hope to gain a better understanding of the protein-protein and protein-RNA interactions that must occur for successful initiation of translation of a specific messenger RNA to occur.

Lab Information

The University of Texas at Austin

Research Area and Skills

Recognize this scientist’s Expertise for their contribution in your research

Biochemistry 0 Molecular Biology 0 Plant Biology 0

More

  • Post
  • Publication
  • Plasmid
  • Following (0)
  • Follower (1)


This guy hasn’t posted anything yet.

Hot Posts for You

Neutralizing antibodies (NAbs) are critical human immune defense mechanisms against viral infections. NAbs can bind to sites on the virus and inhibit entry of that virus into the host. It is a key parameter to evaluate COVID-19 vaccine efficacy per Guidelines from Development and ...Learn More


This 3D animation shows you how DNA is copied in a cell. It shows how both strands of the DNA helix are unzipped and copied to produce two identical DNA molecules. TranscriptDNA is a molecule made up of two strands twisted around each other in a double helix shape. Each strand is ...Learn More


IntroductionA gleam of light finally shone down on the global crisis of the prolonged battle against COVID-19, giving people hopes of preventive care and treatment in the near future by monoclonal antibodies against SARS-CoV-2. As stated the news of NIH’s phase III clinical ...Learn More


"Those who do not know history are obliged to repeat it" This famous phrase that could be from any history teacher to his suspended students has been attributed to great figures in history such as Napoleon or the philosopher George Santayana. In a modern version of it we could say ...Learn More


In recent years there is an increasing number of cytotoxic chemotherapeutic compounds with the ability to rapidly kill dividing cancer cells in preference to non-dividing healthy cells. Nevertheless, the major drawback of chemotherapy is that, in addition to damaging the cancer ...Learn More


The coronavirus pandemic caught everyone unprepared. We had to deal with the fear of an unknown virus which can be lethal for some people. And the whole world just stopped in an attempt to prevent the virus spread.Suddenly we had to adapt to a new way of living, socially isolated ...Learn More


This is the first episode of MolecularCloud Pioneer Scientist interview series. In this interview, MolecularCloud talks with Prof. Shuo Huang from Nanjing University about the recent publications of Dr. Huang’s team and the future prospect of biological nanopore technology. The ...Learn More


The increasing number of confirmed COVID-19 cases is prompting an unprecedented global effort to find a treatment for the disease. Given the fact that a new drug development could be a decade work from initial discovery to the marketplace, scientists are racing to search a cure ...Learn More


The previous article on precision medicine was focused on Pharmacogenomics as a fundamental aspect of cancer therapeutics. In this sequel, emphasis would be on the role of immuno-oncology in personalization of cancer therapy, citing anti PD therapy as an example with hypothetical ...Learn More


  1. Roberts R, Mayberry LK, Browning KS, Rakotondrafara AM. The Triticum Mosaic Virus 5' Leader Binds to Both eIF4G and eIFiso4G for Translation. PLoS One. 12(1):e0169602

  2. Bush MS, Pierrat O, Nibau C, Mikitova V, Zheng T, Corke FM, Vlachonasios K, Mayberry LK, Browning KS, Doonan JH. eIF4A RNA Helicase Associates with Cyclin-Dependent Protein Kinase A in Proliferating Cells and Is Modulated by Phosphorylation. Plant Physiol. 172(1):128-40

  3. Levins E, Tseng CY, Patrick RM, Mayberry LK, Cole N, Browning KS. Fusion proteins of Arabidopsis cap-binding proteins: Cautionary "tails" of woe. Translation (Austin). 4(2):e1257408

  4. Roberts R, Zhang J, Mayberry LK, Tatineni S, Browning KS, Rakotondrafara AM. A Unique 5' Translation Element Discovered in Triticum Mosaic Virus. J Virol. 89(24):12427-40

  5. Browning, K.S. and Bailey-Serres, J. Mechanisms of mRNA translation. Arabidopsis Book 13:e0176


This guy hasn’t plasmids anything yet.

Hot plasmids


This guy has no following anyone.

Popular Cloud Scientists

Cloud Scientists

About Us · User Accounts and Benefits · Privacy Policy · Management Center · FAQs
© 2025 MolecularCloud