Jordan Ward

Jordan Ward is Assistant Professor of MCD Biology at UC Santa Cruz. Ward is leading his lab group towards the research into the mechanisms of gene regulation; they use a combination of genetics, molecular biology, microscopy, in vitro biochemistry, and genomics to determine how individual, evolutionarily conserved transcription factors regulate distinct gene expression programs controlling cell division and differentiation and organ development in living animals, based on the model organism C.elegans. Furthermore, Ward’s lab extend the knowledge acquired to the context of parasite Brugia malayi, which causes lyphatic filariasis, endeavoring to decipher the evolution of gene regulatory networks in a parasite life cycle. In the meantime, being motivated by situations of the public health with respect to the parasitic infection, Ward also anticipates to develop new therapeutic approaches, which target vital developmental processes in parasites, for instance, molting, as it is regulated by various druggable targets (proteases, nuclear hormone receptors, etc.).

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Assistant Professor of MCD Biology, UC Santa Cruz

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Gene Regulation 0 Transcription Factor Regulation 0 Parasitology 0 Organogenesis 0

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  1. Monsalve GC, Yamamoto KR, Ward JD. A New Tool for Inducible Gene Expression in Caenorhabditis elegans. Genetics. 2019 Feb;211(2):419-430. doi: 10.1534/genetics.118.301705. Epub 2018 Nov 30. PubMed PMID: 30504365; PubMed Central PMCID: PMC6366904.

  2. Ward JD. Spotlight on CRISPR in Strongyloides Parasitic Nematodes. Trends Parasitol. 2018 Jan;34(1):6-9. doi: 10.1016/j.pt.2017.11.005. Epub 2017 Nov 23. PubMed PMID: 29174224; PubMed Central PMCID: PMC5748261

  3. Ratnappan R, Ward JD, Yamamoto KR, Ghazi A. Nuclear hormone receptors as mediators of metabolic adaptability following reproductive perturbations. Worm. 2016 Jan-Mar;5(1):e1151609. doi: 10.1080/21624054.2016.1151609. eCollection 2016 Jan-Mar. PubMed PMID: 27073739; PubMed Central PMCID: PMC4805359.

  4. Ward JD. Rendering the Intractable More Tractable: Tools from Caenorhabditis elegans Ripe for Import into Parasitic Nematodes. Genetics.2015 Dec;201(4):1279-94. doi: 10.1534/genetics.115.182717. Review. PubMed PMID: 26644478; PubMed Central PMCID: PMC4676526.

  5. Ward JD. Rapid and precise engineering of the Caenorhabditis elegans genome with lethal mutation co-conversion and inactivation of NHEJ repair.Genetics. 2015 Feb;199(2):363-77. doi: 10.1534/genetics.114.172361. Epub 2014 Dec 9. PubMed PMID: 25491644; PubMed Central PMCID: PMC4317648.


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