Jeff Hasty

Jeff Hasty is a Professor in the Departments of Bioengineering and Molecular Biology, Director of the BioCircuits Institute, and Co-Director of the UC San Diego qBio Ph.D Specialization Program, at the University of California, San Diego. Dr. Hasty is considered a pioneer and leader in synthetic biology; he is the Principal Investigator of the Biodynamics Laboratory (BDL) at UCSD, a lab focuses on the use of engineering methods in the theoretical design and experimental construction of synthetic gene regulatory networks. BDL seeks to understand the network interactions that mediate gene regulation and cellular signaling. Extensive work of Hasty and BDL has been done -- they have successfully engineered a gene network with global intercellular coupling which can generate synchronized oscillations in a growing population of cells, using microfluidic devices tailored for cellular populations at differing length scales. More recently, the lab designed and tested a novel approach to monitor the dynamics of a bacterial population, based on the microelectronics. This approach paves the way for new advances in synthetic biology, analytical chemistry, and microelectronic technologies.

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UCSD Biodynamics Laboratory (BDL), University of California San Diego

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Systems Biology 0 Computational Biology 0 Synthetic Biology 0 Biological Circuits 0 Single-cell Analysis 0 Microfluidic Technology 0

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  1. Li Y, Jiang Y, Paxman J, et al. A programmable fate decision landscape underlies single-cell aging in yeast. Science. 2020;369(6501):325-329. doi:10.1126/science.aax9552

  2. Din MO, Martin A, Razinkov I, Csicsery N, Hasty J. Interfacing gene circuits with microelectronics through engineered population dynamics. Sci Adv. 2020;6(21):eaaz8344. Published 2020 May 22. doi:10.1126/sciadv.aaz8344

  3. Bittihn P, Didovyk A, Tsimring LS, Hasty J. Genetically engineered control of phenotypic structure in microbial colonies. Nat Microbiol. 2020;5(5):697-705. doi:10.1038/s41564-020-0686-0

  4. Miano A, Liao MJ, Hasty J. Inducible cell-to-cell signaling for tunable dynamics in microbial communities. Nat Commun. 2020;11(1):1193. Published 2020 Mar 4. doi:10.1038/s41467-020-15056-8

  5. Graham G, Csicsery N, Stasiowski E, et al. Genome-scale transcriptional dynamics and environmental biosensing. Proc Natl Acad Sci U S A. 2020;117(6):3301-3306. doi:10.1073/pnas.1913003117

  6. Jin M, Li Y, O'Laughlin R, et al. Divergent Aging of Isogenic Yeast Cells Revealed through Single-Cell Phenotypic Dynamics. Cell Syst. 2019;8(3):242-253.e3. doi:10.1016/j.cels.2019.02.002

  7. Baumgartner BL, O'Laughlin R, Jin M, Tsimring LS, Hao N, Hasty J. Flavin-based metabolic cycles are integral features of growth and division in single yeast cells. Sci Rep. 2018;8(1):18045. Published 2018 Dec 21. doi:10.1038/s41598-018-35936-w


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