Hongyan Chen

Hongyan Chen holds a Ph.D. degree in Genetics from Fudan University for her study in genetic treatment Hemophilia B, and she received postdoctoral training at National Neuroscience Institute of Singapore, where she worked on molecular treatment for neuromuscular diseases with genetic basis. Since 2008 Dr Chen has been an Assistant Professor at School of Life Science, Fudan University. Her current research focuses on the molecular mechanisms underlying lung cancer and glioma, aims at revealing novel drug target for cancer diagnosis and treatment. She incorporates gene editing tools particularly CRISPR/Cas9 in experiments to facilitate the operations over genetic materials. In a recent paper of Hongyan’s group, for instance, CRISPR/Cas9 was used to boost the detection of mutant DNA, with their results suggesting the potential of the CRISPR/Cas9 system in the clinical diagnosis and treatment management for heterogeneous specimens (Jia et al., New applications of CRISPR/Cas9 system on mutant DNA detection, 2018). Dr Chen is also exploiting other molecular and diagnostic technologies for future applications.

Lab Information

School of Life Science Fudan University

Research Area and Skills

Recognize this scientist’s Expertise for their contribution in your research

Molecular Biology 0 Targeted Cancer Treatments 0 Glioma 0 Lung Cancer 0 Bioinformatics 0 Hemophilia B 0 CRISPR/Cas9 0

More

  • Post
  • Publication
  • Plasmid
  • Following (0)
  • Follower (1)


This guy hasn’t posted anything yet.

Hot Posts for You

Neutralizing antibodies (NAbs) are critical human immune defense mechanisms against viral infections. NAbs can bind to sites on the virus and inhibit entry of that virus into the host. It is a key parameter to evaluate COVID-19 vaccine efficacy per Guidelines from Development and ...Learn More


This 3D animation shows you how DNA is copied in a cell. It shows how both strands of the DNA helix are unzipped and copied to produce two identical DNA molecules. TranscriptDNA is a molecule made up of two strands twisted around each other in a double helix shape. Each strand is ...Learn More


IntroductionA gleam of light finally shone down on the global crisis of the prolonged battle against COVID-19, giving people hopes of preventive care and treatment in the near future by monoclonal antibodies against SARS-CoV-2. As stated the news of NIH’s phase III clinical ...Learn More


"Those who do not know history are obliged to repeat it" This famous phrase that could be from any history teacher to his suspended students has been attributed to great figures in history such as Napoleon or the philosopher George Santayana. In a modern version of it we could say ...Learn More


In recent years there is an increasing number of cytotoxic chemotherapeutic compounds with the ability to rapidly kill dividing cancer cells in preference to non-dividing healthy cells. Nevertheless, the major drawback of chemotherapy is that, in addition to damaging the cancer ...Learn More


The coronavirus pandemic caught everyone unprepared. We had to deal with the fear of an unknown virus which can be lethal for some people. And the whole world just stopped in an attempt to prevent the virus spread.Suddenly we had to adapt to a new way of living, socially isolated ...Learn More


This is the first episode of MolecularCloud Pioneer Scientist interview series. In this interview, MolecularCloud talks with Prof. Shuo Huang from Nanjing University about the recent publications of Dr. Huang’s team and the future prospect of biological nanopore technology. The ...Learn More


The increasing number of confirmed COVID-19 cases is prompting an unprecedented global effort to find a treatment for the disease. Given the fact that a new drug development could be a decade work from initial discovery to the marketplace, scientists are racing to search a cure ...Learn More


The previous article on precision medicine was focused on Pharmacogenomics as a fundamental aspect of cancer therapeutics. In this sequel, emphasis would be on the role of immuno-oncology in personalization of cancer therapy, citing anti PD therapy as an example with hypothetical ...Learn More


  1. Chen Hongyan, Chen Y, Zhao Y, Fan W, Zhou K, Liu Y, Zhou L, Mao Y, Wei Q, Xu J, Lu D. ssociation of Sequence Variants on Chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) With Glioma Susceptibility in a Chinese Population.Am J Epidemiol. 2011;8:915-22.

  2. S Zhang, Chen Hongyan(并一), X Zhao, J Cao, J Tong, J Lu, W Wu, H Shen, Q Wei, D Lu. REV3L 30UTR 460 T4C polymorphism in microRNA target sites contributes to lung cancer susceptibility. Oncogene. 2013;32(2):242-50

  3. Zhao Y, Chen G, Zhao Y, Song X, Chen Hongyan(通讯), Mao Y, Lu D. Fine-mapping of a region of chromosome 5p15.33 (TERT-CLPTM1L) suggests a novel locus in TERT and a CLPTM1L haplotype are associated with glioma susceptibility in a Chinese population. Int J Cancer. 2011, 7:1569-76.

  4. Xiao Q, Min T, Ma S, Hu L, Chen H, Lu D. Intracellular generation of single-strand template increases the knock-in efficiency by combining CRISPR/Cas9 with AAV. Mol Genet Genomics. 2018;293(4):1051-1060. doi:10.1007/s00438-018-1437-2

  5. Jia C, Huai C, Ding J, et al. New applications of CRISPR/Cas9 system on mutant DNA detection. Gene. 2018;641:55-62. doi:10.1016/j.gene.2017.10.023


This guy hasn’t plasmids anything yet.

Hot plasmids


This guy has no following anyone.

Popular Cloud Scientists

Cloud Scientists

About Us · User Accounts and Benefits · Privacy Policy · Management Center · FAQs
© 2025 MolecularCloud