Gregory Moorhead

Prof Gregory Moorhead holds a Ph.D. degree in Plant Biochemistry from the Queen’s University (Kingston), and did a postdoc study with Philip Cohen in the MRC Protein Phosphorylation Unit at the University of Dundee. Prof. Moorhead has a strong interest in the area of Protein Phosphorylation, and is now a group leader and Professor at the University of Calgary. The Moorhead lab’s primary goal is to define the role of protein phosphatases in cellular events in response to both intra- and extra-cellularly derived signals. The lab uses a combination of biochemistry, molecular cell biology, bioinformatics and proteomics to investigate both human and plant phosphatase function. Current projects include cell cycle control by type one protein phosphatases, novel plant PPP-type phosphatases, protein phosphatase evolution, plant starch phosphatases and proteomics of PP1-complexes.

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University of Calagary

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Protein Phosphorylation 0 Cell Signaling 0 Phosphatases 0 Bioinformatics 0

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  1. Templeton GW, Johnson JJ, Sieben NA, Moorhead GB. GL2 EXPRESSION MODULATOR, a plant specific protein phosphatase one interactor that binds phosphoinositides. Biochem Biophys Res Commun. 2020;528(3):607-611. doi:10.1016/j.bbrc.2020.05.137

  2. Schreier TB, Umhang M, Lee SK, et al. LIKE SEX4 1 Acts as a β-Amylase-Binding Scaffold on Starch Granules during Starch Degradation. Plant Cell. 2019;31(9):2169-2186. doi:10.1105/tpc.19.00089

  3. Kataya ARA, Muench DG, Moorhead GB. A Framework to Investigate Peroxisomal Protein Phosphorylation in Arabidopsis. Trends Plant Sci. 2019;24(4):366-381. doi:10.1016/j.tplants.2018.12.002

  4. Lyons SP, Jenkins NP, Nasa I, et al. A Quantitative Chemical Proteomic Strategy for Profiling Phosphoprotein Phosphatases from Yeast to Humans. Mol Cell Proteomics. 2018;17(12):2448-2461. doi:10.1074/mcp.RA118.000822

  5. White-Gloria C, Johnson JJ, Marritt K, Kataya A, Vahab A, Moorhead GB. Protein Kinases and Phosphatases of the Plastid and Their Potential Role in Starch Metabolism. Front Plant Sci. 2018;9:1032. Published 2018 Jul 17. doi:10.3389/fpls.2018.01032

  6. Nasa I, Rusin SF, Kettenbach AN, Moorhead GB. Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins. Sci Signal. 2018;11(530):eaai8669. Published 2018 May 15. doi:10.1126/scisignal.aai8669


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