Dr. Shao is an Investigator and Deputy Director for Academic Affairs National Institute of Bilogical Sciences, Beijing, China. Recently, he showed that caspase-11, 4 and 5 are cytosolic immune receptors for LPS and activated by direct binding to its lipid A part. Like caspase-1 activation by the canonical inflammasome, caspase-11/4/5 activation induces pyroptosis, both of which are critical for antibacterial defense and development of immunological diseases. Caspase-11/4/5 and caspase-1 cleave Gasdermin D (GSDMD) to release the autoinhibition of its N-terminal domain that bears an intrinsic pore-forming activity for executing pyroptotic cell death.
Research Area and Skills
Recognize this scientist’s Expertise for their contribution in your research
Cell Biology 4 Biochemical Engineering 3 Immunology 1 Pathogen-induced inflammasome activation 1 Biochemical mechanism 1
Zhou P, She Y, Dong N, et al. Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose. Nature. 2018;561(7721):122-126.
Xu Y, Zhou P, Cheng S, Lu Q, Nowak K, Hopp A, Li L, Shi X, Zhou Z, Gao W, Li D, He H, Liu X, Ding J, Hottiger M, Shao F. (2019) A Bacterial effector reveals the V-ATPase-ATG16L1 axis that initiates xenophagy, Cell, 178, 1-15.
Zhou P, She Y, Dong N, Li P, He H, Borio A, Wu Q, Lu S, Ding X, Cao Y, Xu Y, Gao W, Dong M, Ding J, Wang DC, Zamyatina A, Shao F. (2018) Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose, Nature, 561, 122-126 (Published online Aug 15).
Li P, Jiang W, Yu Q, Liu W, Zhou P, Li J, Xu J, Xu B, Wang F & Shao F. (2017) Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defense, Nature, 551, 378-383 (Published online Oct 11).