David Rueda

Dr David Rueda received his PhD degree from EPF Lausanne in 2001, and then he continued to postdoctoral study at the University of Michigan. Following his role as Assistant Professor at Wayne State University, Dr Rueda joined Imperial College London as Professor in 2012. Dr Rueda leads the Single-Molecule Imaging Group, which utilises single-molecule imaging techniques to investigate, with greater specificity, the structural dynamics regulate fundamental biological processes involving proteins and nucleic acids across scales (from individual molecules to cells). The group currently focuses on four research directions in parallel, including the coverage of the popular CRISPR/Cas9, where they want to reveal the mechanisms that determines the on- and off- targets activities of Cas9. The group aims to develop new and improved CRISPR/Cas9 technology to generate accurate and efficient genome editing tools for therapeutic applications. Research of the group also include those on the DNA repair and chromatin remodelling dynamics and the dynamics of SMC complexes. Further, the Rueda group is exploiting the application of Mango RNA aptamers as a new approach to investigate RNA metabolisms, gene expression and chromatin structure in live mammalian cells.

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Imperial College London

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Single-Molecule Imaging Approaches 0 CRISPR/Cas9 Off-Target Mechanisms 0 DNA Repair and Chromatin Remodelling Dynamics 0 SMC Complexes Dynamics 0 Live Cell Single-Molecule Dynamics 0

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  1. Cawte AD, Unrau PJ, Rueda DS. Live cell imaging of single RNA molecules with fluorogenic Mango II arrays. Nat Commun. 2020;11(1):1283. Published 2020 Mar 9. doi:10.1038/s41467-020-14932-7

  2. Gutierrez-Escribano P, Newton MD, Llauró A, et al. A conserved ATP- and Scc2/4-dependent activity for cohesin in tethering DNA molecules. Sci Adv. 2019;5(11):eaay6804. Published 2019 Nov 27. doi:10.1126/sciadv.aay6804

  3. Miura M, Dey S, Ramanayake S, Singh A, Rueda DS, Bangham CRM. Kinetics of HTLV-1 reactivation from latency quantified by single-molecule RNA FISH and stochastic modelling. PLoS Pathog. 2019;15(11):e1008164. Published 2019 Nov 18. doi:10.1371/journal.ppat.1008164

  4. Bruno L, Ramlall V, Studer RA, et al. Selective deployment of transcription factor paralogs with submaximal strength facilitates gene regulation in the immune system. Nat Immunol. 2019;20(10):1372-1380. doi:10.1038/s41590-019-0471-5

  5. Newton MD, Taylor BJ, Driessen RPC, et al. DNA stretching induces Cas9 off-target activity. Nat Struct Mol Biol. 2019;26(3):185-192. doi:10.1038/s41594-019-0188-z


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