Benny Chain

Benny Chain is a Full Professor of Immunology at University College London. He has worked for many years on the biology of the antigen presenting cell, especially on the mechanisms of antigen processing in dendritic cells. In the last few years he has become interested in developing mathematical, statistical and computational tools which will help to integrate and make sense of the huge amounts of data generated by the functional genomics revolution. His research group is now concentrating on using high throughput sequencing to study the regulation of T and B cell receptor repertoire diversity. They focus on the immune response to major pathogens including HIV and Mycobacterium tuberculosis. The research’s major aim is to understand the fundamental rules which regulate the host-pathogen interface.

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Division of Infection and Immunity, University College London

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Computational Immunology 0 Bioinformatics 0 T-cell Receptor Repertoire 0 Antigen Processing and Presenting 0 Carcinogenesis 0

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  1. Ghorani E, Reading JL, Henry JY, et al. The T cell differentiation landscape is shaped by tumour mutations in lung cancer. Nat Cancer. 2020;1(5):546-561. doi:10.1038/s43018-020-0066-y

  2. Biswas D, Birkbak NJ, Rosenthal R, et al. Publisher Correction: A clonal expression biomarker associates with lung cancer mortality. Nat Med. 2020;26(7):1148. doi:10.1038/s41591-020-0899-z

  3. Chemi F, Rothwell DG, McGranahan N, et al. Publisher Correction: Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse. Nat Med. 2020;26(7):1147. doi:10.1038/s41591-020-0865-9

  4. Joshi K, de Massy MR, Ismail M, et al. Publisher Correction: Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer. Nat Med. 2020;26(7):1148. doi:10.1038/s41591-020-0866-8

  5. AbdulJabbar K, Raza SEA, Rosenthal R, et al. Geospatial immune variability illuminates differential evolution of lung adenocarcinoma. Nat Med. 2020;26(7):1054-1062. doi:10.1038/s41591-020-0900-x

  6. López S, Lim EL, Horswell S, et al. Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution. Nat Genet. 2020;52(3):283-293. doi:10.1038/s41588-020-0584-7


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