Andrew Lim

Dr. Andrew Lim completed an MD and residency in neurobiology at University of Toronto and a clinical fellowship at the Beth Israel Deaconess Medical Center in Boston. He is currently a scientist in the Hurvitz Brain Sciences Research Program at Sunnybrook Research Institute, an associate professor of neurology at the University of Toronto and a neurologist at Sunnybrook Health Sciences Centre in Toronto. His research concentrates on sleep and circadian biology, and disorders of which. In detail, Dr. Lim and his team look into the impact of sleep and circadian rhythm on human brain health and underlying neurological mechanisms. They are interested in the genetic mechanisms contributing to human sleep and circadian function, as well as the key molecules that link the circadian rhythm to brain health. Dr. Lim’s lab utilized a diverse range of techniques of different aspects, for instance, wearable monitoring devices for ambulatory at-home measurement of sleep and circadian biology, genetic approaches like GWAS, gene sequencing techniques and analysis methods including linkage to administrative health databases. With those techniques they work on large-scale projects, which include, for example, The Ontario Sleep Health Study.

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University of Toronto

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Sleep and Circadian Biology 0 Neurological Diseases 0 Genetics 0 Noninvasive ambulatory monitoring of sleep and circadian rhythms 0

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  1. Gao L, Lim ASP, Wong PM, et al. Fragmentation of Rest/Activity Patterns in Community-Based Elderly Individuals Predicts Incident Heart Failure. Nat Sci Sleep. 2020;12:299-307. Published 2020 May 27. doi:10.2147/NSS.S253757

  2. Kaneshwaran K, Olah M, Tasaki S, et al. Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer's dementia. Sci Adv. 2019;5(12):eaax7331. Published 2019 Dec 11. doi:10.1126/sciadv.aax7331

  3. Li P, Lim ASP, Gao L, et al. More random motor activity fluctuations predict incident frailty, disability, and mortality. Sci Transl Med. 2019;11(516):eaax1977. doi:10.1126/scitranslmed.aax1977

  4. Wilcox ME, Rubenfeld GD, Walczak KD, Black SE, McAndrews MP, Lim AS. Actigraphic measures of sleep on the wards after ICU discharge. J Crit Care. 2019;54:163-169. doi:10.1016/j.jcrc.2019.08.006

  5. Lim ASP, Gaiteri C, Yu L, et al. Seasonal plasticity of cognition and related biological measures in adults with and without Alzheimer disease: Analysis of multiple cohorts. PLoS Med. 2018;15(9):e1002647. Published 2018 Sep 4. doi:10.1371/journal.pmed.1002647


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