Alexander Mentzer

Dr Alex Mentzer qualified in Medicine from University College London in 2008 and my background is as a trainee in General Medicine with a focus on Infectious Disease. Mentzer is an Infectious Disease doctor working at the John Radcliffe Hospital and a Group Leader at the Wellcome Centre for Human Genetics in the University of Oxford. His research focuses on identifying the genetic factors which contribute to the variation in response to vaccines. His team have developed a multi-national consortium entitled VaccGene which will use powerful modern genetic approaches to incorporate data from many thousands of individuals which will help identify the genetic variants associated with the variation in vaccine response and vaccine failure. Currently as an active researcher in the fight against COVID-19, he is involved in the recruitment and blood sampling of people with a number of infections including COVID both during their acute illness and during their recovery, with a purpose of researching the mechanisms behind varied severity of symptoms of different patients. His group uses a range of cutting edge techniques including genetic and gene expression analyses to determine whether patients’ genetics influence the immune responses so that they can use this information to develop better vaccines, drugs and tests in our fight against infectious disease.

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University of Oxford

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Immunology 0 Genome Wide Association Study 0 Immune Responses 0 COVID-19 0

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  1. Bowyer G, Sharpe H, Venkatraman N, et al. Reduced Ebola vaccine responses in CMV+ young adults is associated with expansion of CD57+KLRG1+ T cells. J Exp Med. 2020;217(7):e20200004. doi:10.1084/jem.20200004

  2. Mentzer AJ, O'Connor D, Pollard AJ, Hill AV; Searching for the human genetic factors standing in the way of universally effective vaccines; Philos Trans R Soc Lond B Biol Sci. 2015;370(1671). pii: 20140341

  3. Mentzer A and Jacobs M; A mass in the liver; BMJ 2013; 346:f2036

  4. Wellcome Trust Case-Control Consortium; Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease Nature 2012;491(7422):119-24

  5. Mentzer A, Perry M, Fitzgerald N, Barrington S, Siddiqui A, Kulasegaram R; Is it all cerebral toxoplasmosis?; Lancet 2012; 379(9812):286

  6. Mentzer A, Karalliedde J, Williams H, Guzder R and Kulasegaram R, Backache with fever: a unique presentation of advanced HIV infection, J AIDS and Clin Research 2010; 1:104

  7. Wellcome Trust Case Control Consortium, Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls, Nature 2010;464(7289):713-20


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