What are the major technical obstacles to develop gene and cell therapy?

Cell therapies, particularly gene-edited cell therapies such as CAR T-cell therapy, are notoriously expensive. The two first CAR T-cell therapies, Yescarta and Kymriah, have been given price tags of $373,000 (€332,764) and $475,000 (€423,773), respectively, in the US, with similar pricing in Europe.

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