AMHR2 (Anti-Mullerian hormone receptor type 2) is a receptor protein that plays a key role in the signaling pathway of Anti-Mullerian hormone (AMH), also known as Mullerian inhibiting substance (MIS). AMHR2 is primarily expressed in the reproductive tissues and is involved in the regulation of sexual development and fertility.

AMH, produced by the Sertoli cells in the testes in males and granulosa cells in the ovaries in females, functions to inhibit the development of the Mullerian ducts during embryonic development. In males, AMH signaling through AMHR2 causes regression of the Mullerian ducts, preventing the formation of female reproductive structures such as the uterus and fallopian tubes. In females, AMH levels decrease after birth, allowing the Mullerian ducts to develop into the uterus, fallopian tubes, and other female reproductive organs.

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