Mia Petljak combines experimental and computational approaches to define active mutational processes in human cancer, study their occurrence and explore their underlying mechanisms.

Ultimately, an understanding of on-going mutagenesis offers the potential to identify novel therapeutic targets and biomarkers for prognosis and therapeutic sensitivity in cancer patients.

Dr. Petljak characterized human cancer cell models that actively acquire many of the mutational signatures identified in cancer and discerned signatures of ongoing from historic mutational processes.

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