Jon Coren

Dr. Coren acquired his PhD degree in Genetics at the Cornell University in 1991, and he completed his academic and industrial postdoc study at Thomas Jefferson from 1991-1993 and DuPont Merck Pharmaceutical company from 1993 – 1997 respectively. Dr. Coren was the associate professor of Biology at the Elizabesthtown College from 2002 to 2018; during that period, his lab’s research centered on the human genome related studies. In particular, the Coren lab carried out research trying to treat cancers by expressing p53 tumor suppressor gene in human tumor cell lines, and, meanwhile, the lab is also interested in the investigation of the optimal transfection reagent for potential gene therapy studies. In 2012, the lab constructed an arrayed 115,000-member human genomic library encapsulated in the P1 Artificial Chromosome (PAC) shuttle vector pJCPAC-Mam2, which can be utilized in genomic studies like genome-wide association studies (GWAS) in both human and animal cell models hence aiding the validation of gene therapy targets.

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Elizabethtown College

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Human genomic library 0 PAC Cloning vector 0 gene therapies 0 pJCPAC-Mam2 0

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Coren, J.S. Retrofitting the BAC cloning vector pBeloBAC11 by the insertion of a mutant loxP site. BMC Res Notes 10, 344 (2017).

Fuesler J, Nagahama Y, Szulewski J, Mundorff J, Bireley S, Coren JS. An arrayed human genomic library constructed in the PAC shuttle vector pJCPAC-Mam2 for genome-wide association studies and gene therapy. Gene. 2012;496(2):103-109. doi:10.1016/j.gene.2012.01.011

Gundersen, E. and Coren, J, 2007. Generating Nested Deletions in PAC Clones Constructed in pJCPAC-Mam2. BIOS 38: 87-94.

Chaterjee, P.K., L.A. Shakes, D.K. Srivastava, D.M. Garland, K.R. Harewood, K.J. Moore and J.S. Coren, 2004. Mutually exclusive recombination of wild-type and mutant loxP sites in vivo facilitates transposon-mediated deletions from both ends of genomic DNA in PACs. NAR 32:5668-5676.

Chaterjee, P.K., S. Mukherjee, L. Shakes, W. Wilson III, J.S. Coren, K.R. Harewood and G. Boyd, 2004. Selecting transpositions using phage P1 headful packaging: new markerless transposons for functionally mapping long-range regulatory sequences in bacterial artificial chromosomes and P1-derived artificial chromosomes. Analytical Biochemistry 335:305-315.

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