Wang Haoyi

1. Xiang G#*, Li Y*, Sun J*, Huo Y*, Cao S, Cao Y, Guo Y, Yang L, Cai Y, Zhang Y#, Wang H#,“Evolution-informed screening and functional characterization of TnpB systems identify highly potent miniature genome editors.” Nature Biotechnology, 2023; Accepted.

2. Song Y* , Chen M* , Zhang Y , Li J, Liu B , Li N , Qiao M , Wang N , Cao Y , Lu S , Chen J, Sun W#, Gao F# , Wang H#.“ Loss of circSRY reduces γH2AX level in germ cells and impairs mouse spermatogenesis.” Life Science Alliance, 2022 Nov; ;6(2): e202201617. doi: 10.26508/lsa. 202201617.

3. Zhang X*, Zhang C*, Qiao M*, Cheng C, Tang N, Lu S, Sun W, Xu B, Cao Y, Wei X, Wang Y, Han W, Wang H#. “Depletion of BATF in CAR-T cells enhances antitumor activity by inducing resistance against exhaustion and formation of central memory cells.” Cancer Cell, 2022; 40(11):1407-1422.e7. (IF2021 38.585, 5年平均41.159)

4. Li G*, Li X*, Zhuang S*, Wang L*, Zhu Y*, Chen Y*, Sun W*, Wu Z*, Zhou Z*, Chen J#, Huang X#, Wang J#, Li D#, Li W#, Wang H#, Wei W#. “Gene editing and its applications in biomedicine.” Science China-Life Sciences, 2022 Apr; 65(4):660-700.( IF2021 10.384, 5年平均7.571)

5. Wu T*, Cao Y*, Liu Q, Wu X, Shang Y, Piao J, Li Y, Dong Y, Liu D, Wang H #, Liu J#, Ding B#. “Genetically Encoded Double-Stranded DNA-Based Nanostructure Folded by a Covalently Bivalent CRISPR/dCas System.” JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2022 Apr; 144(14):6575-6582. (IF2021 16.383, 5年平均16.289)

6. Guo Y*, Xu B*, Wu Z*, Bo J#, Tong C, Chen D, Wang J, Wang H#, Wang Y,# Han W#. “Mutant B2M-HLA-E and B2M-HLA-G fusion proteins protects universal chimeric antigen receptor-modified T cells from allogeneic NK cell-mediated lysis.” EUROPEAN JOURNAL OF IMMUNOLOGY, 2021; 51(10):2513-2521. (IF2020 5.532, 5年平均5.384)

7. Zhao T*, Li Q*, Zhou C*, Lv X, Liu H, Tu T, Tang N, Cheng Y, Liu X, Liu C, Zhao J, Song Z, Wang H, Li J#, Gu F#. “Small-molecule compounds boost genome-editing efficiency of cytosine base editor.” Nucleic Acids esearch, 2021 Sep; 49(15):8974-8986. (IF2021 19.16, 5年平均17.21)

8. Wang Z*, Li N*, Feng K*, Chen M, Zhang Y, Liu Y, Yang Q, Nie J, Tang N, Zhang X, Cheng C, Shen L, He J, Ye X, Cao W#, Wang H#, Han W#. “Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumors.” Cellular & Molecular Immunology, 2021 Aug 11 Online.(IF2020 11.530, 5年平均10.635)

9. Li N, Tang N, Cheng C, Hu T, Wei X, Han W, Wang H#. “Improving the anti-solid tumor efficacy of CAR-T cells by inhibiting adenosine signaling pathway.” OncoImmunology, 2020 Sep 24 ; 9(1): e1824643. （IF2020 8.11，5年平均7.959）

10. Zhang X*; Cheng C*; Sun W; Wang H#. “Engineering T Cells Using CRISPR/Cas9 for Cancer Therapy.” Methods Mol Biol, 2020; 2115: 419-433.

11. Sun W, Wang H#. (2020). “Recent advances of genome editing and related technologies in China”. Gene Therapy, 2020 Aug; 27(7-8): 312-320. （IF2019 4.128，5年平均3.254）

12. An C*, Feng G*, Zhang J, Cao S, Wang Y, Wang N, Lu F, Zhou Q, Wang H#. “Overcoming Autocrine FGF Signaling-Induced Heterogeneity in Naive Human ESCs Enables Modeling of Random X Chromosome Inactivation.” Cell Stem Cell, 2020 Sep; 27（3）: 482-497. （IF2020 26.633，5年平均26.300）

13. Tang N*, Cheng C*, Zhang X, Qiao M, Li N, Mu W, Wei X, Han W, Wang H#. “TGF β Inhibition via CRISPR Promotes the Long-Term Efficacy of CAR-T Cells Against Solid Tumors.” JCI Insight, 2020 Feb; 5(4): e133977. （IF2020 8.315，5年平均8.513）

14. Cao Y*, Sun W*, Wang J, Sheng G, Xiang G, Zhang T, Shi W, Li C, Wang Y, Zhao F#, Wang H#. “Argonaute proteins from human gastrointestinal bacteria catalyze DNA-guided cleavage of single- and double- stranded DNA at 37 °C.” Cell Discovery, 2019; 5:38. (IF2018 4.600)

15. Wang H#，Yang H#. “Gene-edited babies: What went wrong and what could go wrong.” PLOS Biology, 2019 Apr 30；17（4）; e3000224. (IF2020 8.029，5年平均9.570)

16. Mu W*, Tang N*, Cheng C*, Sun W, Wei X, Wang H#. “In vitro transcribed sgRNA causes cell death by inducing interferon release.” Protein & Cell, 2019; 10(6):461–465. (IF2020 14.87，5年平均11.279)

17. Cheng C*, Tang N*, Li J, Cao S, Zhang T, Wei X, Wang H#. “ Bacteria-free minicircle DNA system to generate integration-free CAR-T cells.” Journal of Medical Genetics, 2019 Jan; 56(1): 10-17. (IF2020 6.318，5年平均7.139)

18. Xiang G*, Ren J*, Hai T*, Fu R, Yu D, Wang J, Li W, Wang H#, Zhou Q#. “Editing porcine IGF2 regulatory element improved meat production in Chinese Bama pigs.” Cellular and Molecular Life Sciences. 2018 Dec; 75(24): 4619-4628. (IF2020 9.261，5年平均9.074)

19. Xiang G, Wang H#. “Extended pluripotent stem cells facilitate mouse model generation.” Protein & Cell. 2018; doi: 10.1007/s13238-018-0573-0. (IF2017 6.228，5年平均7.978)

20. Mu W, Zhang Y, Xue X, Liu L, Wei X, Wang H#.” 5′ capped and 3′ polyA-tailed sgRNAs enhance the efficiency of CRISPR-Cas9 system.” Protein & Cell, 2019; 10(3):223-228. (IF2017 6.228，5年平均6.118)

21. Zhang Y, Zhang X, Cheng C, Mu W, Liu X, Li N, Wei X, Liu X, Xia C, Wang H#. “CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells.” Frontiers of Medicine, 2017 Dec; 11(4): 554-562 (IF2017 2.027)

22. Zhang Y, Mu W, Wang H#. “Gene editing in T cell therapy.” Journal of Genetics and Genomics, 2017 Sep; 44 (9) : 415-422(IF2017 4.606，五年平均4.732)

23. Wang H#. “Editing Base in Mouse Model.” Protein & Cell, 2017 Aug; 8(8): 558-559. (IF2017 6.228，5年平均4.326)

24. Xiang G, Zhang X, An C, Cheng C, Wang H#. “Temperature effect on CRISPR-Cas9 mediated genome editing.” Journal of Genetics and Genomics, 2017 Apr; 44(4): 199-205. (IF2017 4.606，五年平均4.732)

25. Liu X, Zhang Y, Cheng C, Cheng WA, Zhang X, Li N, Xia C, Wei X, Liu X, Wang H#. “CRISPR-Cas9 mediated multiplex gene editing in CAR-T cells.” Cell Research, 2017 Jan; 27(1): 154-157. (IF2017 15.393，5年平均15.973)

26. Wang W, Zhang Y, Wang H#. “Generating Mouse Models Using Zygote Electroporation of Nucleases (ZEN) Technology with High Efficiency and Throughput.” Methods in Molecular Biology, 2017; 1605: 219-230.

27. Burgess S, Cheng L#, Gu F, Huang J, Huang Z, Lin S#, Li J, Li W, Qin W, Sun W, Songyang Z, Wei W#, Wu Q, Wang H#, Wang X, Xiong JW, Xi J, Yang H, Zhou B, Zhang B. “Questions about NgAgo” Protein & Cell, 2016 Dec; 7(12): 913-915. (IF2016 5.374，5年平均7.978)

28. Theunissen TW, Friedli M, He Y, Planet E, O'Neil RC, Markoulaki S, Pontis J, Wang H, Iouranova A, Imbeault M, Duc J, Cohen MA, Wert KJ, Castanon R, Zhang Z, Huang Y, Nery JR, Drotar J, Lungjangwa T, Trono D, Ecker JR, Jaenisch R. “Molecular criteria for defining the naive human pluripotent state” Cell Stem Cell, 2016 Oct 6; 19(4): 502-515. (IF2016 23.394，5年平均23.454)

29. 王皓毅，李劲松#，李伟.“基于CRISPR-Cas9新型基因编辑技术研究.”生命科学，2016；28（8）:867-870

30. Wang W, Kutny PM, Byers SL, Longstaff CJ, DaCosta MJ, Pang C, Zhang Y, Taft RA, Buaas FW, Wang H#. “Delivery of Cas9 protein into mouse zygotes through a series of electroporation dramatically increased the efficiency of model creation.” Journal of Genetics and Genomics, 2016 May 20; 43(5): 319-27. (IF2016 4.051，五年平均4.732)

31. Wang, Haoyi(#). CRISPR-Cas9 application in mouse model creation and transcription regulation，13th Transgenic Technology Meeting，捷克布拉格，2016.03.20-2016.03.23 会议论文

32. Qin W, Kutny PM, Maser RS, Dion SL, Lamont JD, Zhang Y, Perry GA, Wang H#.“Generating Mouse Models Using CRISPR-Cas9 Mediated Genome Editing.” Current Protocols in Mouse Biology, 2016 Mar 1; 6(1): 39-66.

33. Cheng AW*#, Jillette N*, Lee P, Plaskon D, Fujiwara Y, Wang W, Taghbalout A, Wang H#. “Casilio: a versatile CRISPR-Cas9-Pumilio hybrid for gene regulation and genomic labeling.” Cell Research, 2016 Feb; 26(2): 254-7. (IF2016 15.606，5年平均20.396)

34. Wiles MV, Qin W, Cheng AW, Wang H#. “CRISPR-Cas9 mediated genome editing and guide RNA design.” Mammalian Genome, 2015 Oct; 26(9-10): 501-10. (IF2015 2.078)

35. Qin W, Dion SL, Kutny PM, Zhang Y, Cheng AW, Jillette NL, Malhotra A, Geurts AM, Chen YG, Wang H#. “Efficient CRISPR/Cas9-mediated genome editing in mice by zygote electroporation of nuclease.” Genetics, 2015 Jun; 200(2):423-30, Epub 2015 Mar 27 (IF2015 4.644)

36. DongC, QuL, Wang H, WeiL, DongY, XiongS.“Targeting hepatitis B virus cccDNA by CRISPR/Cas9 nuclease efficiently inhibits viral replication”Antiviral research2015; 118, 110-117(IF2015 6.984)

37. 项光海，王皓毅#。“靶向核酸酶介导基因编辑技术的发展”生命科学2015；27（1）：12-19.

38. Theunissen T*, Powell B*, Wang H*, Mitalipova M, Faddah D, Reddy J, Fan Z, Maetzel D, Ganz K, Shi L, Lungjangwa T, Imsoonthornruksa S, Stelzer Y, Rangarajan S, D’Alessio A, Zhang J, Gao Q, Dawlaty M, Young R, Gray N, Jaenisch R. “Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency.” Cell Stem Cell, 2014 Oct 2; 15(4): 471-87. (IF2014 22.268)

39. Yang H, Wang H, Jaenisch R. “Generating genetically modified mice using CRISPR/Cas-mediated genome engineering.” Nature protocols, 2014 Aug; 9(8): 1956-68. (IF2014 9.673)

40. Maetzel D*,Sarkar S*, Wang H*, Mosleh LA, Cheng AW, Xu P, Gao Q, Mitalipova M, Jaenisch R. “Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific iPS cells.” Stem Cell Reports, 2014 May 15; 2(6): 866-80. (IF2014 5.365)

41. Sarkar S, Carroll B, Buganim Y, Maetzel D, Ng AH, Cassady JP, Cohen MA, Chakraborty S, Wang H, Spooner E, Ploegh H, Gsponer J, Korolchuk VI, Jaenisch R. “Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease.” Cell Reports, 2013 Dec 12; 5(5): 1302-15. (IF2013 7.207)

42. Li Y, Wang H, Muffat J, Cheng AW, OrlandoDA, Loven J, Rahl P, Kwok SM, Feldman DA, Bateup HS, Hockemeyer D, MitalipovaM, SabatiniBL, Sur M, YoungRA, Jaenisch R. “Global transcriptional repression in human Rett Syndrome neurons suggests therapeutic strategies.” Cell Stem Cell, 2013October 3; 13(4): 446-458. (IF2013 22.151)

43. Cheng AW*, Wang H*, Yang H, Shi L, Katz Y, Rangarajan S, Theunissen TW, Shivalila CS, Dadon DB, Jaenisch R. “Multiplexed activation of endogenous genes by CRISPR-on, a RNA-guided transcriptional activator system.” Cell Research, 2013 October 1; 23(10): 1163-1171. (IF2013 11.981)

44. Yang H*, Wang H*, Shivalila CS*, Cheng AW, Shi L, Jaenisch R. “One-step generation of mice carrying reporter and conditional allele by CRISPR/Cas mediated genome editing” Cell, 2013 September 12; 154(6): 1370-1379. (IF2013 33.116)

45. Faddah D, Wang H, Buganim Y, Cheng AW, Jaenisch R. “Expression of Nanog is biallelic and equally variable as other pluripotency factors.” Cell Stem Cell, 2013 Jul 3; 13(1): 23-9. (IF2013 22.151)

46. Wang H*, Hu YC*, Markoulaki S, Welstead GG, Shivalila CS, Cheng AW, Pyntikova T, Dadon D, Voytas DF, Bogdanove AJ, Page DC, Jaenisch R. “TALEN-mediated editing of the Mouse Y Chromosome.” Nature Biotechnology, 2013 Jun; 31(6): 530-2. (IF2013 39.080)

47. Wang H*, Yang H*, Shivalila CS*, Dawlaty MM, Cheng AW, Zhang F, Jaenisch R. “One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas mediated genome engineering.” Cell, 2013 May 9; 153(4): 910-8. (IF2013 33.116)

48. Qi X, Daily K, Nguyen K, Wang H, Mayhew D, Rigor P, Forouzan S, Johnston M, Mitra RD, Baldi P, Sandmeyer S. “Retrotransposon profiling of RNA polymerase III initiation sites.” Genome Research. 2012 Apr; 22(4): 681-92. (IF2012 14.397)

49. Wang H*, Mayhew D*, Chen X, Johnston M, and Mitra RD. “Calling Cards for DNA-binding proteins in mammalian cells.” Genetics. 2012 Mar; 190(3): 941-9. (IF2012 4.389)

50. Kim J, Su SC, Wang H, Cheng AW, Cassady JP, Lodato MA, Lengner CJ, Chung CY, Dawlaty MM, Tsai LH, Jaenisch R. “Functional integration of dopaminergic neurons directly converted from mouse fibroblasts.” Cell Stem Cell. 2011 Nov 4; 9(5): 413-9. (IF2011 25.421)

51. Hockemeyer D*, Wang H*, Kiani S, Lai CS, Gao Q, Cassady JP, Cost GJ, Zhang L, Santiago Y, Miller JC, Zeitler B, Cherone JM, Meng X, Hinkley SJ, Rebar EJ, Gregory PD, Urnov FD, Jaenisch R. “Genetic engineering of human pluripotent cells using TALE nucleases.”Nature Biotechnology. 2011 Jul 7；29(8): 731-4. (IF2011 23.268)

52. Wang H*, Mayhew D*, Chen X, Johnston M, and Mitra RD. “Calling Cards enable multiplexed identification of the genomic targets of DNA-binding proteins.” Genome Research. 2011 May; 21(5): 748-55. (IF2011 13.608)

53. Hu S, Wang H, Knisely AA, Reddy S, Kovacevic D, Liu Z, Hoffman SMG. “Evolution of the CYP2ABFGST gene cluster in rat, and a fine-scale comparison among rodent and primate species.” Genetica. 2008 Jun; 133(2): 215-26. (IF2008 1.980)

54. Wang H, Heinz ME, Crosby SD, Johnston M, Mitra RD. “Calling Cards method for high-throughput identification of targets of yeast DNA-binding proteins.” Nature Protocols. 2008; 3(10): 1569-77. (IF2008 4.170)

55. Wang H, Johnston M, Mitra RD. “Calling cards for DNA-binding proteins.” Genome Research. 2007 Aug; 17(8): 1202-9. (IF2007 11.224)

56. Wang H, Donley K, Keeney D, Hoffman S. “Organization and evolution of the Cyp2 genecluster on mouse chromosome 7, and a comparison to the syntenic human cluster.”Environmental Health Perspectives. 2003 Nov; 111(15): 1835-42. (IF2003 3.408)

*These authors contribute equally to this work.

#Corresponding author