Research Area
RNA biology in stem cells and biomedicine
Team Description
The Du laboratory was established in 2018, the research of which has focused on identification and studying on posttranscriptional RNA regulatory pathways and exploring their biological relevance in mammalian early embryonic development, ESCs and human disease. As well, Dr. Du is interested in reconstitution of plant unique RNA regulatory pathways in mammalian cells and exploring its potential applications in medicine.
Team Members
Team Show
Publications
1. Ye Qi#, Li Ding#, Siwen Zhang, Shengze Yao, Jennie Ong, Yi Li, Hong Wu, and Peng Du* (2022). A plant immune protein enables broad antitumor response by rescuing microRNA deficiency. Cell, 185:1888-1904. (*Corresponding author)
2. Yanxin Li#, Zhongqiu Li#, Min Yang#, Feiyang Wang#, Yuehong Zhang#, Rong Li, Qian Li, Yunxia Gong, Binhong Wang, Baoguang Fan, Chunyue Wang, Lei Chen, Hong Li, Jennie Ong, Zhaoqian Teng, Lei Jin*, Yan-Ling Wang*, Peng Du* and Jianwei Jiao* (2022). Decoding the temporal and regional specification of microglia in the developing human brain. Cell Stem Cell, 29: 620-634. (*Corresponding author)
3. Hui Shen#, Min Yang#, Shiyu Li#, Jing Zhang, Bing Peng, Chunhui Wang, Zai Chang, Jennie Ong, and Peng Du* (2021). Mouse totipotent stem cells captured through spliceosomal repression. Cell.184:2843-2859.(*Corresponding author)
4. Yingzi Cui#, Xuehui Lyu#, Li Ding, Lan Ke, Dechang Yang, Mehdi Pirouz, Ye Qi, Jennie Ong, Ge Gao, Peng Du*, and Richard I. Gregory* (2021). Global miRNA dosage control of embryonic germ layer specification. Nature.593:602-606. (*Corresponding author)
5. Choe J, Lin S, Zhang W, Liu Q, Wang L, Ramirez-Moya J, Du P, Kim W, Tang S, Sliz P, Santisteban P, George RE, Richards WG, Wong KK, Locker N, Slack FJ, Gregory RI (2018). mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Nature. 561:556-560.
6. Park HH, Triboulet R, Bentler M, Guda S, Du P, Xu H, Gregory RI, Brendel C, Williams DA (2018). DROSHA Knockout Leads to Enhancement of Viral Titers for Vectors Encoding miRNA-Adapted shRNAs. Mollecular Therapy. 12:591-599.
7. Du P, Pirouz M, Choi J, Huebner AJ, Clement K, Meissner A, Hochedlinger K, and Gregory RI (2018). An Intermediate Pluripotent State Controlled by microRNAs is Required for the Naïve to Primed Stem Cell Transition. Cell Stem Cell. 22:851-864.
8. Pirouz M, Du P, Munafò M, Gregory RI (2016). Dis3l2-Mediated Decay Is a Quality Control Pathway for Noncoding RNAs. Cell Reports. 16:1861-73.
9. Lin S, Choe J, Du P, Triboulet R and Gregory RI (2016). METTL3 promotes translation in human cancer cells. Molecular Cell. 62:335-45.
10. Du P, Wang L, Sliz P, Gregory RI (2015). A Biogenesis Step Upstream of Microprocessor Controls miR-17∼92 Expression. Cell. 162:885-99.
11. Guda S, Brendel C, Renella R, Du P, Bauer DE, Canver MC, Grenier JK, Grimson AW, Kamran SC, Thornton J, de Boer H, Root DE, Milsom MD, Orkin SH, Gregory RI, Williams DA (2015). miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction. Molecular Therapy 10.1038
12. Thornton JE, Du P, Jing L, Sjekloca L, Lin S, Grossi E, Sliz P, Zon LI, Gregory RI (2014). Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4). Nucleic Acids Res. 42:11777-91
13. Cao MJ#, Du P#, Wang XB, Li Y, Ding SW (2014). Virus infection triggers widespread silencing of host genes by a distinct class of endogenous siRNAs in Arabidopsis. PNAS. 111:14613-8. (# Co-first auther).
14. Du P#, Wu JG#, Zhang J, Zhao SQ, Zheng H, Gao G, Wei L, Li Y. (2011) Viral Infection Induces Expression of Novel Phased MicroRNAs from Conserved Cellular MicroRNA Precursors. PLoS Pathogens. 7:e1002176 (# Co-first author).