Research Area

5-MER peptide (5-MP; Methionine Threonine, Alanine, Aspartic Acid, Valin) inhibits the pathology of animal models of chronic inflammations such as Rheumatoid Arthritis , Inflammatory Bowel Disease ,multiple Sclerosis as well as animal models of fibrosis, including systemic sclerosis, idiopathic pulmonary fibrosis (IPF) and severe lung fibrotic damage in COVID-19 infection. The peptide was derived from a sequence of 5 amino acids of pro-inflammatory CD44 variant , that involved in the pathology of this protein (J. Clin. Invest. 111, 1211-1220, 2003). The peptide targets and neutralizes Serum Amyloid A (SAA), which fuels the release of pro-inflammatory cytokine (IL-6, IL-1 beta and TNFalfa) from activated fibroblasts and monocytes , resulting with inflammatory damage to the body tissue (J Autoimmun . 2021 Nov; 124:102713). Further, the peptide activates genes , which protect against chronic inflammation and neurodegeneration. However, the peptide does not interfere with normal immune responses, such anti-infection antibodies stressing its specificity . 5-MP suppresses cytokine release of pro-inflammatory cytokines and proliferation of fibroblasts and monocytes involved in chronic inflammation and fibrosis . These findings suggest that 5-MP could be a promising drug for chronic inflammation and fibrosis-associated diseases, displaying an unmet therapeutic needs. Indeed, the 5-MP showed lack of toxicity in phase-1 clinical trial. For these research achievements professor Naor received the prestige 2021 kaye prize of the Hebrew University of Jerusalem for scientific innovation .

Team Description

Dr Hassan Elsana, a post doc , exploring the effect of 5-MP on Amyloid beta of Alzheimer disease showing encouraging results. Dr. Rawan Atiq,a post doc, exploring the targeting mechasnism of 5-MP Dr Toshiyuki Murai, a Japanese collaborator on the effect of 5-MP on Amyloid beta. Dr. Maayan Hemed Shaked , a post doc , exploring the effect of 5-MP on chronic inflammation. Dr Keren-Or Amar, a postdoc . exploring the the effect of 5-MP rheumatoid Arthritis Dr Shmuel Cohen, a collaborator , Co-principle investigator.

Team Members

Dr Hassan Elsana
Dr. Rawan Atiq
Dr Toshiyuki Murai
Dr. Maayan Hemed Shaked
Dr Keren-Or Amar, a postdoc
Dr Shmuel Cohen, a collaborator

Team Show

Publications

PUBLICATION LIST

1. A. Shulov and D. Naor. Experiments on the olfactory responses and host-specificity of the oriental rat flea (Xenopsylla Cheopis). Parasitology 54:225-231, 1964.

2. M. Ickowicz, A. Shulov and D. Naor. The effect of Vipera Palestina venom on the thymus and lymph nodes. Harefuah 70:265-266, 1966.

3. M. Ickowicz, A. Shulov and D. Naor. The effect of Vipera Palestina venom on the thymus, lymph nodes and kidneys. Toxicon 3:305-306, 1966.

4. D. Naor and D. Sulitzeanu. Binding of radioiodinated bovine serum albumin to mouse spleen cells. Nature 214:687-688, 1967.

5. D. Naor and D. Sulitzeanu. Binding of radioiodinated bovine serum albumin to lymphoid cells specifically primed or immunized mice in vitro. Life Sciences. 7:(2),377-382, 1969.

6. D. Naor and D. Sulitzeanu. Affinity of radioiodinated bovine serum albumin for lymphoid cells. Binding of I125BSA to lymphoid cells of immune mice. Israel J. Med. Sci. 5:217-229, 1969.

7. D. Sulitzeanu and D. Naor. The affinity of radioiodinated BSA for lymphoid cells.Binding of 125I-BSA to lymphoid cells of normal mice. Int. Arch. Allergy Appl. Immunol.35:564-578, 1969.

8. Naor, Z. Bentwich and G. Cividalli. Inability of peripheral lymphoid cells of agammaglobulinaemic patients to bind radioiodinated albumins. Aust. J. Exp. Biol.Med. Sci. 47:(6) 759-761, 1969.

9. D. Naor and D. Sulitzeanu. Binding of 125I-BSA to lymphoid cells of tolerant mice.Int. Arch. Allergy Appl. Immunol. 36:112-113, 1969.

10. D. Naor. Antigen uptake by lymphoid cells of normal, immune and tolerant mice.Ph.D. thesis, 1968.

11. D. Naor and D. Sulitzeanu. The affinity of radioiodinated bovine serum albumin for lymphoid cells. II. Further experiments with cells of normal animals. Israel J. Med. Sci.6:519-522, 1970.

12. D. Naor, R.I. Mishell and L. Wofsy. Specific inhibition of an anti-hapten immune response by chemical modification of cells. Immunol. 105:1322-1326, 1970.

13. Wofsy, P. Truffa-Bachi and D. Naor. Chemical approaches to the cell receptor problem. Annals. N.Y. Acad. Sci. 190:432-442, 1971.

14. D. Naor, C. Henry and H. Fudenberg. An in vitro immune response to penicillin. J. Immunol. 107:302-305, 1971.

15. D. Naor and R. Mishell. In vitro immunity to TNP and penicillin. Specific inhibition with hapten-conjugated isologous red cells. J. Immunol. 108:246-252, 1972.

16. D. Naor, S. Morecki and E. Kedar. Differential induction and suppression of direct and indirect PFC responses to TNP conjugated to heterologous erythrocytes. Adv. Exp. Med. Biol. 29:225-232, 1972.22naor/cv-dn.doc

17. D. Sulitzeanu, S. Morecki, D. Naor and R. Tanenbaum. Specific interactions of antigens with cells. In: 3rd International Convocation on Immunology, D. Pressman, T.B. Tomasi, Jr., A.L. Grossberg, N.R. Rose, (eds), pp.354-368, Karger, Basel. 1973.

18. D. Naor, S. Morecki and G.F. Mitchell. Differential induction of anti-trinitrophenyl plaque forming cell responses to lightly and heavily conjugated trinitrophenylated heterologous and autologous erythrocytes in mice. Eur. J. Immunol.4:311-314, 1974.

19. S. Zolla, D. Naor and P. Tanapatchaiyapong. Cellular basis of of immunodepression in mice with plasmacytomas. J. Immunol. 112:2068-2076, 1974.

20. D. Sulitzeanu, S. Morecki and D. Naor. Specific interaction of antigen with cells studied by means of rosette formation. Israel J. Med. Sci. 10:1397-1404, 1974.

21. S. Zolla and D. Naor. Restoration of immune competence in tolerant mice by parabiosis to normal mice. J. Exp. Med. 5:1421-1426, 1974.

22. D. Naor, R. Saltoun and F. Falkenberg. Lack of requirement for thymocytes for efficient antibody formation to trinitrophenylated mouse red cells in mice: role for thymocytes in suppression of the immune response. Eur. J. Immunol. 5:220-223, 1975.

23. S. Zolla, F. Falkenberg and D. Naor. Is tolerance an active or a defective state? Proceedings of the Fifth International Congress of the Transplantation Society, (eds.,M. Schlesinger and R.E. Billingham) Transplant. Proc. 7, Suppl. 1 pp. 381-383, 1975.

24. D. Naor, R. Berman-Goldman, M. Kahan, H. Goldfisher, R. Laskov, E. Simon and R. Tchakirov. Induction of hapten recognizng helper function by heavily trinitrophenylated sheep erythrocytes erythrocytes. Adv. Exp. Med. Biol. 66:253-260,1975.

25. M. Kahan, R. Berman-Goldman, R. Saltoun and D. Naor. Studies on the immune response to fixed antigens. Preferential induction of helper function with heavily trinitrophenylated sheep erythrocytes and glutaraldehyde treated sheep erythrocytes. J. Immunol. 117:16-22, 1976.

26. N. Galili, D. Naor, B. Asjo and G. Klein. Induction of immune responsiveness in genetically low-responsive tumor host combination by chemical modification of the immunogen. Eur. J. Immunol. 6:473-476, 1976.

27. D. Naor and N. Galili. Immune response to chemically modified antigens. Review article. Prog. Allergy 22:107-146, 1977.

28. E. Kedar, E. Unger,N. Galili, G. Klein, B. Asjo, B. Bonavida and D. Naor. Immunogenicity of tumor cells modified by trinitrobenzene sulfonic acid (TNBS). In: Membranes and neoplasia. New approaches and strategies. V.T. Marchesi (ed), pp.109-121, Alan R. Liss, New York, 1976.

29. D. Naor, B. Bonavida, R.A. Robinson, I.N. Shibata, D.E. Percy, D. Chia and E.V. Barnett. Immune response of New Zealand (NZB and NZB/W) mice to trinitrophenylated mouse red cells. Eur. J. Immunol. 6:783-789, 1976.

30. D. Naor, B. Bonavida and R.L. Walford. Autoimmunity and aging: The age-related 33naor/cv-dn.doc response of a long-lived strain to trinitrophenylated syngeneic mouse red blood cells. J. Immunol. 117:2204-2208, 1976.

31. D. Naor and C. O`Toole. Cryopreservation of immunological memory and other lymphoid cell functions. J. Immunol. Methods 16:361-370, 1977.

32. D. Naor and M. Kahan. Studies on the immune response to fixed antigens. II. Optimal conditions for inducing and eliciting helper function by fixed antigens and the mechanism responsible for this effect. Israel J. Med. Sci. 13:561-576, 1977.

33. D. Naor. Immune surveillance against autoimmunity. Review paper. In: Dynamic aspects of host-parasite relationship. V.3. A. Zukerman (ed.), pp. 9-31, Keter, Jerusalem, 1979.

34. R.F. Ashman and D. Naor. Defective receptor capping and regeneration in the antigen binding cells of tolerant mice. In: Immune system: genetics and regulation.

E.E. Sercarz, L. Herzenberg and C.F. Fox (eds.), pp. 707-711, Academic Press, New York, 1977.

35. D. Naor. Delayed type hypersensitivity. Encyclopedia Hebraica. V. 30 pp. 501-504,1978.

36. D. Naor. Suppressor cells: Permitters and promoters of malignancy? Invited review.Adv. Cancer Res. 29:45-125, 1979.

37. B. Leshem and D. Naor. Cellular assay for measuring anti-erythrocyte antibody responses. J. Immunol. Methods 20:263-275,1978.

38. N. Galili, B. Devens, D. Naor, S. Becker and E. Klein. Immune responses to weakly immunogenic virally induced tumors. I. Overcoming low responsiveness by priming

mice with a syngeneic in vitro tumor line or allogeneic cross-reactive tumor. Eur. J. Immunol. 8:17-22, 1978.

39. B. Devens, N. Galili, O. Deutsch, D. Naor and E. Klein. Immune responses to weakly immunogenic virally induced tumors. II. Suppressive effects of the in vivo carried tumor YAC. Eur. J. Immunol. 8:573-578, 1978.

40. B. Leshem and D. Naor. Studies on the immune response to fixed antigens. III. Induction of helper function for antibody dependent cellular cytotoxicity responses. J. Immunol. 121:401-408, 1978.

41. E. Klein, S. Becker, N. Galili, B. Devens and D. Naor. Cell mediated cytotoxic reactions against oncorna virus induced lymphomas in mice. In: Proceedings of Erwin Riesch Symposium on Cytotoxic Cell-Interaction and Immunostimulation. 1979.

42. R.F. Ashman and D. Naor. Membrane defects of the tolerant B cell. I. Failure of antigen-induced capping. Cell. Immunol. 44:314-328, 1979.

43. B. Devens and D. Naor. Immune responses to weakly immunogenic virally induced tumors. III. Genetically unrestricted cytolysis of allogeneic tumor target cells. J.Immunol. 122:1397-1401, 1979.

44. B. Devens, L. Schochat and D. Naor. Immune responses to weakly immunogenic virally induced tumors. V. Short in vitro cultivation of YAC changes its antigenic44naor/cv-dn.doc

properties. Cell. Immunol. 44:442-453, 1979.

45. B. Leshem and D. Naor. Studies on the immune response to fixed antigens. IV.Recall of immunologic memory with fixed antigens. Israel J. Med. Sci. 16:25-32, 1980.

46. B. Devens, D. Naor and E. Kedar. Immune response to weakly immunogenic virally induced tumors. IV. Dissociated recognition of H-2 and tumor-associated antigens.Transplantation 28:389-395, 1979.

47. D. Naor. Unresponsiveness to modified self antigens. A censorship mechanism controlling autoimmunity. Invited review. Immunological Reviews 50:187-226, 1980.

48. B. Devens, N. Galili, D. Naor and E. Klein. Opposing tumorogenic and immunogenic properties of the in vitro and the in vivo sublines of Moloney induced tumor. In: Cell Biology and Immunology of Leukocyte Function. M.R. Quastel (ed.) pp. 707-714.Academic Press, New York, 1979.

49. O. Deutsch, B. Devens and D. Naor. Immune responses to weakly immunogenic murine-leukemia-virus induced tumors. VII. Kinetic studies on various parameters of effects induced with suppressor cells. Isr. J. Med. Sci. 16:530-537, 1980.

50. O. Deutsch, B. Devens and D. Naor. Immune responses to weakly immunogenic murine-leukemia-virus-induced tumors. VIII. Characterization of suppressor cells. Isr. J. Med. Sci. 16:538-544, 1980.

51. B. Devens and D. Naor. Immune responses to weakly immunogenic virally induced tumors. VI. Comparison of the immune response of the hybrid to the immune responses of the parents reveals "hybrid responsiveness" effect. J. Immunol. 125:988-994. 1980.

52. B.Y. Klein, S. Frenkel, A. Ahituv and D. Naor. Immunogenicity of subcellular fractions and molecular species of MuLV-induced tumors. I. Screening of immunogenic components by isopycnic ultracentrifugation and polyacrylamide electrophoresis of a tumor homogenate. J. Immunol. Methods 38:325-341, 1980.

53. B.Y. Klein, B. Devens, O. Deutsch, A. Ahituv, S. Frenkel, B.J. Kobrin and D. Naor. Isolation of immunogenic and suppressogenic determinants of nonimmunogenic YAC tumor and the change in its immunogenic repertoire after in vitro cultivation.Transplant. Proc. 8:790-797, 1981.

54. B.J. Kobrin, D. Naor and B.Y. Klein. Immunogenicity of subcellular fractions and molecular species of MuLV-induced tumors. II. Stimulation of syngeneic anti-tumor cell-mediated immune responses by subcellular fractions and molecular species of the Rauscher-virus-induced RBL5 tumor. J. Immunol. 125:1874-1882, 1981.

55. R. Sharon, B.Y. Klein, Y. Avraham, N. Kaner, N. Tarcic and and D. Naor. The change of immunogenic repertoire of YAC tumor cells after in vitro cultivation. In: Proceedings of the 14th International Leucocyte Conference. Mechanisms of lymphocyte activation. K. Resch and H. Kirchner, (eds.) pp. 636-639. Elsevier/North Holland Biomedical Press, Amsterdam, 1981.

56. B. Devens, O. Deutsch, Y. Avraham and D. Naor. Immune responses to weakly immunogenic virally induced tumors. IX. Mice injected with the in vitro variants of YAC tumor (YAC-1) resist lethal doses of the tumorgenic YAC cells. Immunobiology 55naor/cv-dn.doc 159:432-443, 1981.

57. D. Naor, B.Y. Klein and R. Sharon. T cells and cancer.Proceedings of the XIth Triennial World Congress of Pathology. Advances in Pathology 1:293-298, 1982.

58. D. Naor and N. Tarcic. Control of autoimmune responses induced with modified self antigens. Annals N.Y. Acad. Sci. 392: 178-190, 1982.

59. B.Y. Klein, R. Sharon, N. Tarcic and D. Naor. Induction of antitumor reactive cells or suppressor cells by different molecular species isolated from the same non-immunogenic tumor. Immunobiology 163:7-21, 1982.

60. A. Ahituv, D. Naor, R. Sharon, N. Tarcic and B.Y. Klein.Immunogenicity of subcellular fractions and molecular species of of MuLV-induced tumors. III. Stimulation of syngeneic antitumor responses by subcellular fractions and molecular species of Moloney virus-induced tumors in CBA and A mice. Cancer Immunol. Immunother.14:16-26, 1982.

61. B.Y. Klein, R. Sharon, Y. Avraham, A. Ahituv and D. Naor. Isolation of immunogenic entities from nonimmunogenic transplantable tumors and their normal cell counterparts. Transplant. Proc. 15:225-231, 1983.

62. N. Tarcic and D. Naor. Delayed-type hypersensitivity induced in immunodeficient mice

with syngeneic modified self antigens: A suggestive model of autoimmune response.

Eur. J. Immunol. 12:961-966, 1982.

63. N. Tarcic, R. Sharon, E. Rosenmann and D. Naor. Auto-delayed type hypersensitivity

(DTH) induced in immunodeficient mice with syngeneic modified self antigens. II.

Suppressor T cells control the autoimmune response. Scand. J. Immunol. 19:111-

121, 1984.

64. D. Naor. Coexistence of immunogenic and suppresssogenic epitopes in tumor cells

and various types of macromolecules. Invited editorial review. Cancer Immunol.

Immunother. 16:1-10, 1983.

65. A. Adler, J.A. Stein, E. Kedar, D. Naor and D.W. Weiss. Intralesional injection of IL-2

expanded autologous lymphocytes in melanoma and breast cancer patients. A pilot

study. J. Biol. Resp. Modifiers. 3:491-500, 1984.

66. I. Klein and D. Naor. Self reactive delayed type hyper-sensitivity (DTH) induced in

mice by syngeneic lymphoblasts. Immunobiology. 169:45-59, 1985.

67. N. Tarcic, R. Baler and D. Naor. Auto-delayed-type hypersensitivity (DTH) induced in

immunodeficient mice with modified self antigens. III. Suppressive T cell factor (SF)

controls the autoreactivity against self antigens. Scand. J. Immunol. 20:389-401,

1984.

68. N. Tarcic, B.Y. Klein and D. Naor. Auto-delayed-type hypersensitivity (DTH) induced

in immunodeficient mice with modified self antigens. IV. Characterization of the

suppressive T cell factor (SF) that controls the autoreactivity against self antigens.

Scand. J. Immunol. 20:403-411, 1984.

69. D. Naor and J.S. Duke-Cohan. Suppressor cells and malignancy, I. Suppressor

macrophages and suppressor T cells in experimental animals. Invited review.

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Advances in Immunity and Cancer Therapy, Vol. 2. pp 1-129 P.K.Ray (ed.)

Springer-Verlag, New York, 1986.

70. B.Y. Klein, S. Frenkel and D. Naor. Isolated soluble fractions from the murine B16

melanoma induce primary in vitro syngeneic antitumor responses. Cancer Immunol.

Immunother. 18:195-202, 1984.

71. R. Sharon and D. Naor. The isolation of immunogenic molecular entities from

immunogenic and non-immunogenic tumor homogenates by sodium dodecyl sulfate

polyacrylamide gel electrophoresis (SDS-PAGE). Cancer Immunol. Immunother.

18:203-208, 1984.

72. J.S. Duke-Cohan, H. Weinberg, R. Sharon and D. Naor. Immunological function in

Osteoporosis. Clin. Immunol. Immunopathol. 35:125-129, 1985.

73. D. Naor, B.Y. Klein, N. Tarcic and J.S. Duke-Cohan. Immunosuppression in human

malignancy. Humana Press, New Jersey, 1988.

74. P. Hutchings, D. Naor and A. Cooke. Effects of low doses of cyclophosphamide and

low doses of irradiation on the regulation of induced erythrocyte autoantibodies in

mice. Immunology. 54:97-104, 1985.

75. D. Naor and A. Langer. Analysis of the cyclosporin (CSA) mechanism in

immunological autoreactive model of delayed type hypersensitivity. Transplant. Proc.

17:2706-2708, 1985.

76. D. Naor, N. Tarcic and R. Baler. Control of in vivo immunological autoreactivities with

suppressive T cell factor (TF) derived from hybridoma cell line. Transplant. Proc.

17:2617-2621, 1985.

77. A. Langer, E. Rosenmann and D. Naor. The effect of cyclosporin on murine

autoreactive delayed type hypersensitivity induced with syngeneic lymphoblasts.

Immunopharmacology. 10:147-155, 1985.

78. D. Naor, N. Tarcic, I. Klein, and A. Langer. Immunological autoreactivity to

lymphoblast antigens and its suppression by cyclosporin (CsA) or suppressor T cell

factors (TsFs). UCLA Symposia on Molecular and Cellular Biology, New Series,

Volume 41. Immune Regulation by Characterized Polypeptides. G. Goldstein, J.F.

Bach, H. Wigzell (eds.), Alan R. Liss, Inc., New York, pp. 165-179, 1987.

79. J.S. Duke-Cohan, I. Leichter, N. Husseini, R. Sharon, J.Stessman, D. Naor and H.

Weinberg. Immune function in Osteoporosis: A central role for peripheral blood

monocytes in immune suppression and Osteopaenia. Proc. of the 7th International

Workshop on Calcified Tissue. Ein Gedi, Israel, 1986. Current Advances in

Skeletogenesis. 3:304-310, 1986 .

80. N. Tarcic and D. Naor. The genetic control of syngeneic delayed type hypersensitivity

(syn-DTH). Immunogenetics. 24:31-134, 1986.

81. D. Naor. Suppressor cells and human malignancy. Clin. Immun. Newsletter. 8: 65-

69, 1987.

82. V.E. Kelley, D. Naor, N. Tarcic, C.N. Gaulton, and T.B. Strom. Anti-Interleukein 2

receptor antibody suppresses delayed-type hypersensitivity to foreign and syngeneic

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antigens. J. Immunol. 137:2122-2124, 1986.

83. J.S. Duke-Cohan, R. Hirt, A. Dahan, and D. Naor. On the immune reaction to

autologous human lymphoblasts: Evidence for the stimulation by activating factors

rather than induction by autoantigens. Clin. Immunol. Immunopathol. 43:229-242,

1987.

84. I. Klein, B.Y. Klein, and D. Naor. Self-reactive delayed type hypersensitivity induced in

mice by syngeneic lymphoblasts. II. Isolation of two distinct lymphoblast antigens, one

of which reacts (or cross-reacts) with anti-H-2Dd monoclonal antibody. Scand. J.

Immunol. 27: 209-222, 1988.

85. I. Klein, and D. Naor. Self-reactive delayed type hypersensitivity induced in mice by

syngeneic lymphoblasts. III. Immunological characterization of the small and large

antigens of the blast cells. Scand. J. Immunol. 27:385-392, 1988.

86. R. Sharon, H. Giloh, and D. Naor. Experimental autoimmune anemia induced with

haptenated syngeneic mouse red blood cells and low dose X-irradiation. Clin.

Immunol. Immunopathol. 47: 310-322, 1988.

87. D. Naor, N. Tarcic, P. De Berardinis, M. Kahan, and M. Feldmann. Autoreactivity

against class I or class II antigens -- immunological downregulation mechanism? Bull.

Inst. Pasteur, 87:3-17, 1989.

88. J.S. Duke-Cohan, R. Hirt, M. Rottem, A. Ben-Zvi, A. Rubinow, and D. Naor. Use of an

autologous reaction in vitro to assess contributions of T and B lymphocytes to immune

hyperreactivity of atopics. Clin. Exp. Allergy 19, 163-168, 1989.

89. D. Naor, G. Essery, M. Kahan, and M. Feldmann. T-cell clone anti-clone interactions

effects on suppressor and helper activities. J. Autoimmun. 2 (Supp.), 3-14, 1989.

90. R. Sharon and D. Naor. Experimental model of autoimmune hemolytic anemia

induced in mice with Levodopa. Clin. Immunol. Immunopathol., 52, 160-172, 1989.

91. I. Klein and D. Naor. Autoinflammatory response to self-antigens of lymphoblasts.

Isr. J. Med. Sci. 24:373-375, 1988.

92. N. Tarcic, C. S. David and D. Naor. Auto-delayed-type hypersensitivity induced in

immunodeficient mice with modifed self-antigens. V. Cellular autoreactivity directed

against self-H-2Dd subregion mediates the inflammatory responses.Immunology,

67:184-190, 1989.

93. H. Lugasi, S. Hajos, J. R. Murphy, T. B. Strom, J. Nichols, C. Penarroja and D. Naor.

Murine spontaneous T cell leukemia constitutively expressing IL-2 receptor-a model

for human T cell malignancies expressing IL-2 receptor. Int. J. Cancer, 45:163-167,

1990.

94. J. S. Duke-Cohan, A. Rubinow, R. Hirt and D. Naor. The reaction against autologous

lymphoblasts as an indicator of lymphocyte hyperreactivity in rheumatoid arthritis.

Clin. Immunol. Immunopathol., 54:298-308, 1990.

95. E. Alvarez, C. Mongini, C.I. Waldner, T.B. Fenandez, D. Naor and S.E. Hajos. The

inter-relationships between spontaneous murine T cell leukemia LB and the immune

system: LB is a nonimmunogenic tumor in its syngeneic host. J. Exp. Clin. Cancer

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Res. 8, 181-191, 1989.

96. D. Naor, G. Essery, N. Tarcic, M. Kahan and M. Feldmann. Interactions between

autologous T cell clones. Cell Immunol. 128:490-502, 1990.

97. D. Naor, G. Essery, N. Tarcic, M. Kahan, J.R. Lamb and M. Feldmann. Specific

interactions between a human CD4+ clone and autologous CD4+ bifunctional

immunoregulatory clones. Immunol. Rev. 116, 63-83, 1990.

98. M.A. Zahalka and D. Naor. Inflammatory Response induced with an isolated

syngeneic activation antigen shared by normal lymphoblasts and YAC lymphoma

cells. Clin. Immunol. Immunopathol. 59:72-88, 199l.

99. Naor, D. Essery, G. Tarcic, N. Kahan, M. and Feldmann, M. Regulatory interactions

among autologous T cell clones human bifunctional T cell clones regulate the activity

of an autologous T cell clone. Ann. N. Y. Academy of Sciences. 636, 135-146, 199l.

100. Naor, D. Short analytical review. A different outlook at the phenotype-function

relationships of T cell Subpopulations. Fundamental and clinical implications. Clin

Immunol. Immunopathol. 62, 127-132, 1991.

101. Pillemer, G., Lugasi-Evgi, H., Scharovsky, G., and Naor, D. Insulin dependence of

murine lymphoid T cell leukemia. Int. J. Cancer. 50, 80-85, l992.

102. Sharon, R. and Naor, D. Experimental model of autoimmune hemolytic anemia

induced in mice with levodopa by intraperitoneal injection or oral feeding. Int. J.

Immunopharmac. 14, 1241-1247, 1992.

103. Naor, D. Bifunctional T cell clones challenge the traditional compartmentalization

concept of the immune system. Arch. Immunol. Ther. Exp. 40, 67-70, 1992.

104. Sharon, R., Pillemer, G., Ish-Shalom, D., Kalman, R., Ziv, E., Berry, M.E. and Naor,

D. Insulin dependence of murine T-cell lymphoma II. Insulin deficient diabetic mice

develop resistance to the lymphoma growth. Int. J. Cancer., 53, 843-849, 1993.

105. Sharon, R. Polliack, A., Rahamim, E., Kahane, A. and Naor, D. Autoimmune

hemolytic anemia induced with levadopa or -methyldopa animal model and clinical

implications. Advances in Allergy and Immunology. 2, 65-78, 1993.

106. Zahalka, M.A. Okon, E. and Naor, D. Blocking lymphoma invasiveness with

monoclonal antibody directed against the ß chain of the leukocyte adhesion molecule

(CD18). J. Immunol. 150, 4466-4477, 1993.

107. Zahalka, M.A. and Naor, D. ß2-Integrin dependent aggregate formation between

LB T cell lymphoma and spleen cells: assessment of correlation with spleen

invasiveness. International Immunol. 6, 917-924, 1994.

108. Ish-Shalom, D., Tzivion, G., Cristoffersen, C.T., Urso, B., De Meyts, P. and Naor,

D., Mitogenic potential of insulin and lymphoma cells lacking IGF-I receptor. Ann.

N.Y. Acad. Sci. 776, 409-415.

109. Stock, R. and Naor, D. Induction of an autoimmune response against syngeneic

lymphoma cells by immunogenic 64-kDa protein isolated from normal balst cells of

BALB/c mice. Cancer Immunol. Immunother. 40, 48-56, 1995.

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110. Zahalka, M.A., Okon, E., Gosslar, U., Holzmann, B. and Naor, D. Lymph node (but

not spleen) invasion by murine lymphoma is both CD44 and Hyaluronate-dependent.

J. Immunol. 154, 5345-5355, 1995.

111. Naor, D., Vogt Sionov, R., and Ish-Shalom, D. CD44: Structure, function and its

association with the malignant process. Adv. Cancer Res., 71, 241-319, 1997

112. Naor, D. CD44. Encyclopedia of Immunology. Academic Press, London. 487-491,

1998.

113. Gosslar, U., Jonas, P., Luz, A., Lifka, A., Naor, D., Hamann, A., and Holzmann, B.

Predominant role of (4-integrins for distinct steps of lymphoma metastasis. Proc. Natl.

Acad. Sci. USA vol. 93, 4821-4826, 1996.

114. Rocha, M., Kruger, A. Umansky, V., von Hoegen, P., Naor, D., and Schirrmacher,

V. Dynamic expression changes in vivo of adhesion and costimulatory molecules

determine load and pattern of lymphoma liver metastasis. Clin. Cancer Res. 2, 811-

820, 1996.

115. Naor, D., Vogt Sionov, R., Zahalka, M., Kantor, B., Rochman, M., Holzmann, B. and

Ish-Shalom, D. Organ-specific requirements for cell adhesion molecules during

lymphoma cell dissemination. Curr. Top. Microbiol. Immunol. 231, 143-166, 1998

116. Ish-Shalom, D., Christoffersen, C.T., Vorwerk, P., Sacerdoti-Sierra, N., Shymko,

R.M., Naor, D. and De Meyts, P. Mitogenic properties of insulin and insulin analogues

mediated by the insulin receptor. Diabetologia. 40, S25-S31, 1997

117. Vogt Sionov, R. and Naor, D. Hyaluronan-independent lodgement of CD44+

lymphoma cells in lymphoid organs. Int. J. Cancer. 71, 462-469, 1997.

118. Vogt Sionov, R. and Naor, D. Calcium-and calmodulin-dependent PMA-activation of

CD44 adhesion molecule. Cell Adhesion and Communication. 6: 503-523, 1998.

119. Rochman, M., Moll, J., Herrlich, P., Wallach, S.B., Nedvetzki, S., Vogt Sionov, R.,

Golan, I., Ish-Shalom, D., and Naor, D. The CD44 receptor of lymphoma cells:

structure-function relationships and mechanism of action. Cell Adhesion and

Communication. 7, 331-347, 2000.

120. Nedvetzki, S., Walmsley, M., Alpert, E., Williams, R.O., Feldmann, M. and Naor, D.

CD44 involvement in experiment collagen-induced arthritis (CIA). J. Autoimmunity.

13, 39-47, 1999.

121. Wallach, S B.., Friedmann, A., and Naor, D. The CD44 receptor of the mouse LB T

cell lymphoma: Analysis of the isoform repertoire and ligand binding properties by

reverse-transcriptase polymerase chain reaction (RT-PCR) and anti-sense

oligonucleotides. Cancer Detection and Prevention. 24, 33-45, 2000.

122. Weiss, L., Slavin, S., Reich, S., Cohen, P., Shuster, S., Stern, R., Kaganovsky, E.,

Okon, E., Rubinstein, A.M., and Naor, D. Induction of resistance to diabetes in non-

obese diabetic mice by targeting CD44 with specific monoclonal antibody. Proc. Natl.

Acad. Sci. USA. 97, 285-290, 2000.

123. Naor, D. CD44. Encyclopedia of Molecular Medicine. John Wiley & Sons. Invited

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entry. 2000.

124. Naor, D., Nedvetzki, S., Golan, I. and Faitelson, Y. CD44 in Cancer. Critical

Reviews in Clinical Laboratory Sciences. 39, 527-579, 2002

125. Wallach-Dayan, S. B., Grabovsky, V., Moll, J., Sleeman, J., Herrlich, P., Alon, R.

and Naor, D. CD44-dependent lymphoma cell dissemination: a cell surface CD44

variant, rather than standard CD44, supports in vitro lymphoma cell rolling on

hyaluronic acid substrate and its in vivo accumulation in the peripheral lymph nodes.

Journal of Cell Science. 114, 3463-3477, 2001

126. Naor, D. and Nedvetzki, S. CD44 in Rheumatoid Arthritis. Arthritis Research &

Therapy. 5, 105-115, 2003.

127. Guy, R., Yefenof, E, Naor D., Dorogin, A. and Zilberman, Y. CD44 co-stimulates

apoptosis in thymic lymphomas and T cell hybridomas. Cell. Immunol. 216, 82-92,

2002.

128. Melnik, L., Rochman, M., Ronen, D., Zick, Y. Naor, D., and Golan, I. Identification

of Novel CD44 Ligands May Provide New Targets for Therapy. In: Proceedings of the

2 nd International Conference on Tumor Microenvironment Progression, Therapy &

Prevention, Isaac P. Witz (ed.),pp. 213-220, Monduzzi Editore, Bologna, Italy, 2002.

129. Urso, B., Ilondo, M. M., Holst, P.A., Christoffersen, C.T., Ouwnes., M.,

Giorgetti, S. Van, Obberghen, E., Naor, D., Tornqvist, H., and De Meyts, P. IRS-4

mediated mitrogenic signalling by insulin and growth harmone in LB cells, a murine T-

cell lymphoma devoid of IGF-I receptors. Cellular Signalling. 5630, 1-10, 2002.

130. Nedvetzki, S., Golan, I., Assayag, N., Gonen, E., Caspi, D., Gladnikoff M.Yayon,A.,

and Naor, D. A mutation in a CD44 variant of inflammatory cells enhances the mitogenic

interaction of FGF with its receptor. J. Clin. Invest. 111, 1211-1220, 2003.

131. Avigdor, A., Goichberg, P., Shivtiel, S., Dar, A., Peled, A., Samira, S., Kollet, O.,

Hershkoviz, R., Alon, R., Hardan, I., Ben-Hur, H., Naor, D., Nagler, A., and Lapidot, T.

CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+

stem/progenitor cells to the bone marrow. Blood. 103,2981-2989,2004.

132. Nedvetzki,S.,Gonen, E.,Assayag,N.,Reich, R,,Williams, R.O.,Thurmond,R.L.,Huang,J-

F.,Neudecker,B.A.,F.,Wang,F-S.,Turley,E.A. and Naor,D. RHAMM,a receptor for

hyaluronan-mediated motility compensates for CD44 in inflamed CD44-knockout mice: a

different interpretation of redundancy. PNAS 101,18081-18086,2004.

133. Naor,D and Assayag N. The lesson to be learned from CD44 knockout mice.In

Hyaluronan 2003. Proceedings(eds:Balazs,E.A.and Hascall V.C). Matrix Biology Institute

2004.

134. Tolg,C., Hamilton,S.R, Naor,D., McCarthy,J.B. and Turley,E.A. Analysis of convergent

divergent signaling pathways regulated by Rhamm and CD44: Identification of Actin

Cytoskeleton proteins AS Rhamm binding partners. In Hyaluronan 2003.

Proceedings(eds:Balazs,E.A.and Hascall V.C). Matrix Biology Institute,2004.

135. Naor,D., Nedvetzki,S., Assayag,N., Thurmond,R.L.,Huang J-F.and E.A.Turley. The

mechanism of molecular redundancy in autoimmune inflamation in the context of CD44

deficiency. Ann.N.Y.Acad.Sci.1050,52-63,2005

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136. Golan I , Nedvetzki S , Golan I , Eshkar-Sebban L , Levartovsky D , Elkayam O , Caspi D ,

Aamar S , Amital H , Rubinow A , Naor D . Expression of extra trinucleotide in CD44 variant

of rheumatoid arthritis patients allows generation of disease-specific monoclonal antibody.

J Autoimmun. 28: 99-113, 2007.

137. Garin T , Rubinstein A , Grigoriadis N , Nedvetzki S , Abramsky O , Mizrachi-Koll R , Hand

C , Naor D , Karussis D . CD44 variant DNA vaccination with virtual lymph node ameliorates

experimental autoimmune encephalomyelitis through the induction of apoptosis. J Neurol

Sci. 258:17-26, 2007.

138. Lora Eshkar Sebban, Denise Ronen, David Levartovsky, Ori Elkayam, Dan Caspi ,

Suhail Aamar, Howard Amital, Alan Rubinow, Ira Golan, David Naor, Yehiel Zick and

Itshak Golan. The Involvement of CD44 and its Novel Ligand Galectin-8 in Apoptotic

Regulation of Autoimmune Inflammation. J Immunol. 179:1225-1235, 2007.

139. David Naor, Shlomo Nedvetzki, Marita Walmsley, Avner Yayon, Eva A. Turley, Ira

Golan, Dan Caspi, Lora Eshkar Sebban, Yehiel Zick, Tali Garin, Dimitrios Karussis,

Nathalie Assayag-Asherie, Itamar Raz, Lola Weiss, Shimon Slavin and Itshak Golan.

CD44 involvement in autoimmune inflammations: The lesson to be learned from CD44-

targeting by antibody or from knock out mice. Ann NY Acad Sci. 1110:233-47, 2007.

140. Naor D, Wallach-Dayan SB, Zahalka MA, Sionov RV. Involvement of CD44, a molecule

with a thousand faces, in cancer dissemination. Semin Cancer Biol.18:260-267,2008.

141. Weiss L, Botero-Anug AM, Hand C, Slavin S, Naor D. CD44 gene vaccination for

insulin-dependent diabetes mellitus in non-obese diabetic mice. Isr Med Assoc J.10:20-

5,2008

142 . Gonen E, Nedvetzki S, Naor D, Shpigel NY. CD44 is highly expressed on milk

neutrophils in bovine mastitis and plays a role in their adhesion to matrix and mammary

epithelium. Vet Res. 2008 39:29,2008.

143. Shulamit Batya Wallach-Dayan, Ariel M. Rubinstein, Carla Hand, Raphael Breuer

and David Naor DNA Vaccination with CD44 Variant Isoform Reduce Mammary Tumor

Local Growth and Lung Metastasis. Molecular Cancer Therapeutic (MCT). 7:1615-1623 ,

2008.

144. Vagima Y , Avigdor A , Goichberg P , Shivtiel S , Tesio M , Kalinkovich A , Golan K , Dar

A , Kollet O , Petit I , Perl O , Rosenthal E , Resnick I , Hardan I , Gellman YN , Naor D ,

Nagler A , Lapidot T .MT1-MMP and RECK are involved in human CD34+ progenitor

cell retention, egress, and mobilization. J Clin Invest. 119:492-503, 2009.

145. Kahaly GJ, Shimony O, Gellman YN, Lytton SD, Eshkar-Sebban L,Rosenblum N,

Refaeli E, Kassem S, Ilany J, and Naor D Regulatory T-cell in Graves’ orbitopathy:

Baseline findings and immunomodulation by anti-T lymphocyte globulin. J Clin Endocrinol

Met (JCEM). 96: 422-429,2011.

146. Turley EA, and Naor D. RHAMM and CD44 peptides-analytic tools and potential drugs

2011. Front Biosci. 17:1775-1794, 2012.

147. Shimony O,Nagler A,Gellman YN, Refaeli E, Rosenblum N. Eshkar-Sebban L

Yerushalmi R, Shimoni A, Lytton SD, Stanevsky A,Or R, Naor D. Anti-T lymphocyte

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globulin (ATG) induces generation of Regulatory T Cells, at least part of them

express

activated CD44. J Clin Immunol 32:173–188 , 2012

148. Girbl T , Hinterseer E , Grössinger EM , Asslaber D , Oberascher K , Weiss L , Hauser-

Kronberger C , Neureiter D , Kerschbaum H , Naor D , Alon R , Greil R , Hartmann TN .

CD40- mediated activation of chronic lymphocytic leukemia cells promotes their CD44-

dependent adhesion to hyaluronan and restricts CCL21 induced motility. Cancer Res.

73(2):561-570, 2013

149. Benjamin Gesundheit MD PhD 1 , Joshua Rosenzweig MD 1 , David Naor PhD 2 ,

Armand Keating MD 3 , Bernard Lerer MD 4 , Dizah Zachor MD 5 , Vaclav Procházka MD

PhD 6 , Michal Melamed PhD 1 , Donald A. Kristt MD 5 , Abraham Steinberg MD 8 , Cory

Shulman PhD 9 , Paul Hwang MD 10 , Gideon Koren MD 11 , Asnat Walfish MD 12 , Vijendra

Singh PhD 13 , Basan Gowda S Kurkalli PhD 14 , Jacob R Passweg MD 15 , John Snowden

MD 16 , Ryad Tamouza MD PhD 17 , Marion Leboyer MD PhD 18 , Dominique Farge-Bancel

MD 19 , Paul Ashwood PhD 20 . Autoimmunity and Autism Spectrum Disorders. J

Autoimmun. 2013 44:1-7, 2013

150. Gesundheit B, Ashwood P, Keating A, Naor D, Melamed M, Rosenzweig J

Therapeutic properties of mesenchymal stem cells for autism spectrum disorders. Med

Hypotheses. 2015 Mar;84(3):169-77.

151. Nathalie Assayag-Asherie, Dror Sever, Marika Bogdani, Pamela Johnson, Talya

Weiss, Ariel Ginzberg, Sharon Perles, Lola Weiss, Lora Eshkar Sebban, Eva A. Turley,

Elimelech Okon, Itamar Raz, and David Naor. Can CD44 be a mediator of cell

destruction ? the challenge of type 1 diabetes . PLoS One. 2015; 10(12): e0143589

152. David Naor .Editorial: Interaction between hyaluronic acid and its receptors

(CD44,RHAMM) regulates the activity of inflammation and cancer . Front. Immunol.

7:39.doi: 10.3389/fimmu.2016.00039

153. Barzilay R, Ventorp F, Segal-Gavish H, Aharony I, Bieber A, Dar S, Vescan M,

Globus R, Weizman A, Naor D, Lipton J, Janelidze S, Brundin L, Offen D.CD44

Deficiency Is Associated with Increased Susceptibility to Stress-Induced Anxiety-like

Behavior in Mice. J Mol Neurosci. 2016 Sep 13.

154. Pinner E, Gruper Y, Ben Zimra M, Kristt D, Laudon M, Naor D, Zisapel N CD44

Splice Variants as Potential Players in Alzheimer's Disease Pathology. J Alzheimers Dis.

58(4):1137-1149. 2017

155. Beider K, Naor D, Voevoda V, Ostrovsky O, Bitner H, Rosenberg E, Varda-Bloom

N, Canaani J, Danilesko I, Shimoni A, and Nagler A., Dissecting the mechanisms

involved in anti-human T-lymphocyteimmunoglobulin (ATG)-induced tolerance in the

setting of allogeneic stem cell transplantation - potential implications for Graft versus

Host Disease. Oncotarget, 8(53):90748-90765, 2017

156. Toshiyuki Murai, Hiroto Kawashima and David Naor. Editorial: Cell-Cell and Cell-

Matrix Adhesion in Immunobiology and Cancer. Front. Immunol. 10:3126. doi:

10.3389/fimmu.2019.03126

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157. D. Naor, M. Hemed-Shaked, M. Cowman, J Kim, J. Armengol, J. Alemany,

D.Kanduc, A human-derived 5-mer peptide (MTADV), which restrictively alleviates the pro-

inflammatory activity of serum amyloid a (SAA), substantially ameliorates IBD pathology: new

potential drug (MTADV) and therapeutic target candidate (SAA) for IBD. Inflamm. Bowel Dis.

6:S3–4 (2020)

158. Maayan Hemed-Shaked , Mary K Cowman , Jin Ryoun Kim , Xiayun Huang , Edward

Chau, Haim Ovadia, Keren-Or Amar , Lora Eshkar-Sebban , Michal Melamed , Libat Bar

Lev , Eli Kedar , Jordi Armengol , Jorge Alemany , Shaul Beyth, Eli Okon, Darja Kanduc,

Sharona Elgavish , Shulamit B Wallach-Dayan , Shmuel Jaffe Cohen , David Naor

MTADV 5-MER peptide suppresses chronic inflammations as well as autoimmune

pathologies and unveils a new potential target-Serum Amyloid A . J Autoimmun . 2021 Nov;

124:102713

159. David Naor, Mary Cowman, Jin Kim, Maayan Hemed-Shaked . MTADV 5-MER

PEPTIDE SUPPRESSES IBD PATHOLOGY AND UNVEILS A NEW POTENTIAL TARGET-

SERUM AMYLOID A. Gastroenterology Vol. 162, No. 3S.