Sandra Gabelli

Dr Gabelli's research focuses on elucidating the molecular mechanism of proteins involved in cell signaling pathways modulated by the second messenger phosphatidylinositol 3,4,5 triphosphate, (PIP3). To achieve a comprehensive understanding I am studying cytoplasmic protein-protein interactions involved in regulation of pathways such as PI3K and Na transporters. Many of these pathways are deregulated in diseases such as diarrhea, diabetes, inflammation and cancer. Her research integrates structural biology and chemical biology and it is focused on drug discovery. Dr. Gabelli is using biochemical and biophysical techniques including X-ray crystallography, SAXS, ITC, Mass spectrometry, AUC.

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John Hopkins School of Medicine

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Cell signaling pathways 1 Structural biology 1 Drug discovery 0 X-ray crystallography 0 SAXS 0 Protein expression and purification 0

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  1. Boto AN, Xu W, Jakoncic J, Pannuri A, Romeo T, Bessman MJ, Gabelli SB, Amzel LM. Structural studies of the Nudix GDP-mannose hydrolase from E. coli reveals a new motif for mannose recognition. Proteins. 2011 Aug;79(8):2455-66.

  2. Duong-Ly KC, Gabelli SB, Xu W, Dunn CA, Schoeffield AJ, Bessman MJ, Amzel LM. The Nudix hydrolase CDP-Chase, a CDP-choline pyrophosphatase, is an asymmetric dimer with two distinct enzymatic activities. J Bacteriol. 2011 Jul;193(13):3175-85.

  3. Gabelli SB, Duong-Ly K, Brower ET, Amzel LM . Capitalizing on tumor genotyping: Towards the design of mutation specific inhibitors of phosphoinsitide-3-kinase. Adv Enzyme Regul. 2011;51(1):273-9.


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