Juan Antonio Bernal Rodríguez

Juan A. Bernal holds a degree in Biological Sciences (University of Seville, 1999) and Specialist in Molecular and Cellular Biology (University of Seville, 2001), defended his PhD thesis in 2004 at the Institute of Natural Resources and Agrobiology of the CSIC in the laboratory by Dr Jose A Pintor-Toro on the role of oncogenes in inhibiting the transcriptional activity of the p53 tumor suppressor. With an EMBO scholarship (Long Term) he moved to England to begin his postdoctoral stage. During the 6 years of postdoc in the laboratory of Ashok Venkitaraman (Hutchison MRC Center for Translational Research, Cambridge, UK, 2004-2010) he worked on different aspects of DNA metabolism, since the initiation of replication, through how the structure changes of DNA after gene damage, up to a relationship of problems during the initiation of replication with the segregation of sister chromatids during cytokinesis. In 2010 he rejoined the Spanish research system,focusing on the development of new models of study of human diseases in induced pluripotent cells (iPS), as well as in animal systems. Using a new method to generate tissue-specific transgenics, it is able to transduce wild animals with adeno-associated viruses to express genes that induce right ventricular arrhythmogenic cardiomyopathy (ARVC) or hyperlipidemia using (AAV). These viruses are generally used as tools in gene therapy and have adapted them to generate transgenic animals. Thanks to these new models, he has been able to demonstrate, for example, that extreme exercise is a trigger for the development of ARVC. After an external scientific evaluation, since April 2015 he has been Group Chief (Assistant Professor) at the National Center for Cardiovascular Research (CNIC), as well as Scientific Advisor to the Viral Vectors Unit.

Lab Information

CNIC(Spanish National Cardiovascular Research Centre)

Research Area and Skills

Recognize this scientist’s Expertise for their contribution in your research

Inherited cardiomyopathies 0 Pluripotent cells (iPS) 0

More

  • Post
  • Publication
  • Plasmid
  • Following (0)
  • Follower (2)


This guy hasn’t posted anything yet.

Hot Posts for You

Neutralizing antibodies (NAbs) are critical human immune defense mechanisms against viral infections. NAbs can bind to sites on the virus and inhibit entry of that virus into the host. It is a key parameter to evaluate COVID-19 vaccine efficacy per Guidelines from Development and ...Learn More


This 3D animation shows you how DNA is copied in a cell. It shows how both strands of the DNA helix are unzipped and copied to produce two identical DNA molecules. TranscriptDNA is a molecule made up of two strands twisted around each other in a double helix shape. Each strand is ...Learn More


IntroductionA gleam of light finally shone down on the global crisis of the prolonged battle against COVID-19, giving people hopes of preventive care and treatment in the near future by monoclonal antibodies against SARS-CoV-2. As stated the news of NIH’s phase III clinical ...Learn More


"Those who do not know history are obliged to repeat it" This famous phrase that could be from any history teacher to his suspended students has been attributed to great figures in history such as Napoleon or the philosopher George Santayana. In a modern version of it we could say ...Learn More


In recent years there is an increasing number of cytotoxic chemotherapeutic compounds with the ability to rapidly kill dividing cancer cells in preference to non-dividing healthy cells. Nevertheless, the major drawback of chemotherapy is that, in addition to damaging the cancer ...Learn More


The coronavirus pandemic caught everyone unprepared. We had to deal with the fear of an unknown virus which can be lethal for some people. And the whole world just stopped in an attempt to prevent the virus spread.Suddenly we had to adapt to a new way of living, socially isolated ...Learn More


This is the first episode of MolecularCloud Pioneer Scientist interview series. In this interview, MolecularCloud talks with Prof. Shuo Huang from Nanjing University about the recent publications of Dr. Huang’s team and the future prospect of biological nanopore technology. The ...Learn More


The increasing number of confirmed COVID-19 cases is prompting an unprecedented global effort to find a treatment for the disease. Given the fact that a new drug development could be a decade work from initial discovery to the marketplace, scientists are racing to search a cure ...Learn More


The previous article on precision medicine was focused on Pharmacogenomics as a fundamental aspect of cancer therapeutics. In this sequel, emphasis would be on the role of immuno-oncology in personalization of cancer therapy, citing anti PD therapy as an example with hypothetical ...Learn More


  1. Ayoub N, Jeyasekharan AD, Bernal JA, Venkitaraman AR. HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response. Nature. 2008;453(7195):682-6.

  2. Sangrithi MN, Bernal JA, Madine M, et al. Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome. Cell. 2005;121(6):887-98.

  3. Bernal JA, Luna R, Espina A, et al. Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis. Nat Genet. 2002;32(2):306-11.


This guy hasn’t plasmids anything yet.

Hot plasmids


This guy has no following anyone.

Popular Cloud Scientists

Cloud Scientists

About Us · User Accounts and Benefits · Privacy Policy · Management Center · FAQs
© 2024 MolecularCloud